A purine analogue, 2-aminopurine, reported to act as an inhibitor of protein kinase, selectively, reversibly and in a dose-dependent manner blocked a very early stage in interferon induction. With chick embryo cells and mouse L cells as hosts, and different viral inducers of interferon, maximal effects of 2-aminopurine were observed during the first 4 h of induction. At 10 mM-2-aminopurine ther...

Mendelian susceptibility to mycobacterial diseases (MSMD) are a spectrum of inherited disorders characterized by localized or disseminated infections caused by atypical mycobacteria. Interferon-γ receptor 1 (IFNGR1) deficiency was the first identified genetic disorder recognized as MSMD. Mutations in the genes encoding IFNGR1 can be recessive or dominant and cause complete or partial receptor d...

The murine suppressive factor of allergy (SFA) has been purified from a T-cell hybridoma and found to consist of two functionally and biochemically distinct protein molecules. One protein (17 kDa) modulates the low-affinity Fc receptor for IgE on lymphocytes (i.e., CD23); it decreases the binding avidity of IgE to CD23-bearing B cells without affecting quantitative expression of CD23 and is thu...

Introduction Gain-of-function mutations in IFIH1 were identified in Aicardi-Goutières syndrome (AGS), a rare neuroimmunological disorder associated with elevated levels of type I interferon and characterized by leucoencephalopathy, brain atrophy and intracranial calcifications leading to profound intellectual disability, spasticity and dystonia. IFIH1 functions as an intracellular innate immune...

Background: Angiotensin I converting enzyme 2 (ACE2) is a receptor for the severe acute respiratory syndrome coronavirus (SARS-CoV-2) and differences in its expression may affect susceptibility to infection. Methods: We performed genome-wide quantitative trait loci (eQTL) analysis using hepatitis C virus-infected liver tissue from ...

Many severe forms of COVID-19 have genetic causes, with variants providing information and thus supporting the hypothesis that moderate-intensity exercise would a prophylactic role. In case abnormalities related to induction amplification type I interferons, in addition curative administration interferon, moderate intensity could be used prophylactically. The same exercises inhibit p38 MAPK pat...

The anti-viral immune response is dependent on the ability of infected cells to sense foreign nucleic acids. In multiple species, pattern recognition receptor (PRR) cyclic GMP-AMP synthase (cGAS) senses viral DNA as an essential component innate response. cGAS initiates a range signaling outputs that are generation second messenger cGAMP binds adaptor protein stimulator interferon genes (STING)...