Previous studies showed that interleukin-6 (IL-6) was expressed in human Leydig and Sertoli cells and that it inhibited sperm motility. The aim of this study was to compare the expression of IL-6, IL-6R, and GP130 in ejaculated spermatozoa between normozoospermic and asthenozoospermic men. Human spermatozoa in the semen were purified by Percoll gradient technique to separate the seminal plasma ...

The cultural supernatant of Mycoplasma fermentans induced interleukin-6 production by human gingival fibroblasts. The active entities were divided into hydrophilic and hydrophobic substances. In this study, we purified a 4.1-kilodalton polypeptide from the hydrophilic substances. It reacted with polyclonal antibodies to M. fermentans and activated human macrophages.

The helical cytokine interleukin-6 (IL-6) assembles a multiprotein receptor complex. The starting event in the activation of intracellular signaling is the binding of the IL-6/IL-6R alpha subcomplex to two gp130 chains. The homodimerization of gp130 is triggered by two distinct and independent regions of IL-6 called sites 2 and 3. Several IL-6 antagonists have been obtained that affect signalin...

objective(s):although recent investigations have shown chronic inflammation and inflammation-associated diseases might be ameliorated by exercise; little is known about the relation between exercise training with anti/pro-inflammatory cytokines. materials and methods: this cross sectional study was conducted to compare interleukin-4 (il-4), il-6, il-10, il-12, il-13, interferon gamma (ifn-γ) le...

All-trans-retinoic acid (ATRA), a vitamin A derivative, was reported to suppress the interleukin-6 (IL-6) production and to downregulate the IL-6 receptor (IL-6R) and/or its signal transducer glycoprotein 130. We investigated the in vivo antinephritic effect of ATRA on IL-6 transgenic mice which had developed mesangial proliferative glomerulonephritis (PGN) as well as its in vitro inhibitory ef...

Enhanced chemoresistance is, among other factors, believed to be responsible for treatment failure and tumor relapse in patients with epithelial ovarian cancer (EOC). Here, we exposed EOC cells to interleukin-6 (IL-6) to activate oncogenic STAT3, which directly repressed miR-204 via a conserved STAT3-binding site near the TRPM3 promoter region upstream of miR-204. Repression of miR-204 was requ...

background: approximately 10-14% of the clinically acknowledged pregnancies end with spontaneous abortion at caucasian population. possible immunologic causes of recurrent miscarriages have been extensively researched. the change in the cytokines balance synthesis in favor of those synthesized by th2 cells with an increase of interleukin 6 (il6) and interleukin10 (il10) secretion is considered ...

Background: Intraventricular hemorrhage (IVH) in preterm neonates is a serious problem in neonatal intensive care units (NICU) worldwide. IVH is reported in approximately 60-70% of very-low-birth-weight (VLBW) neonates. The present study aimed to assess the association of IVH with neonatal characteristics and serum markers, such as serum Interleukin-6 (IL-6) level, in preterm neonates in an aca...

Background: The immunologic profile of chronic urticaria is not only important for diagnostic purposes, but also for therapeutic approaches. This study evaluated the serum levels of Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF-α) and Interferon-ϒ (IFN-ϒ) in patients with chronic urticaria to find a biomarker.Materials and Methods: Forty-one patients with chronic urticaria referring to the...