Purpose: The aim of this study was to evaluate the protective effect resveratrol on cisplatin induced damage in rat kidney.
 Materials and Methods: 30 female Wistar-Albino rats were allocated form three groups: In group 1 (control group), mL 0.9% NaCl (saline) administered intraperitoneally for 3 days. 2 (cisplatin 7.5 mg / kg intraperitoneal given + group) 10 via route. Right kidneys surg...

The roots of Hymenocardia acida are used in traditional African medicine to treat mainly erectile dysfunction. This study aims evaluate the lethal and sub-lethal toxicities aqueous extract two rodents species, namely Mus musculus Rattus norvegicus. acute intraperitoneal oral were determined by method Miller Tainter. Subchronic toxicity with doses 500 1000 mg/kg body weight was assessed accordin...

Distribution and balance studies with carbon-14-labeled amphotericin B methyl ester (AME) were carried out in mice. The radioactive AME was administered by either the intraperitoneal (i.p.) or intravenous (i.v.) route. In the organ distribution study, the percent radioactivity accumulating in the lung of i.v. treated mice at 1 hour after administration was about 150 times greater than that ob...

Using the intraperitoneal route of infection, we demonstrated previously that A/Sn mice are resistant and B10.A mice are susceptible to Paracoccidioides brasiliensis infection. Since paracoccidioidomycosis is a deep systemic granulomatous disorder that involves primarily the lungs and then disseminates to other organs and systems, we herein investigated the course of the infection and the resul...

Two yellow fever virus (YFV)/dengue virus chimeras which encode the prM and E proteins of either dengue virus serotype 2 (dengue-2 virus) or dengue-4 virus within the genome of the YFV 17D strain (YF5.2iv infectious clone) were constructed and characterized for their properties in cell culture and as experimental vaccines in mice. The prM and E proteins appeared to be properly processed and gly...

recent publication [1] and for reporting their very interesting experiments showing that intraperitoneal but not subcutaneous simvastatin inhibits arthritis progression in the mouse collagen-induced arthritis (CIA) model [2]. Th ese results are in line with those of Palmer and colleagues, who showed that intraperitoneal but not oral simvastatin administration inhibited pre-existing CIA [3]. Acc...

BACKGROUND Differing factors may alter the effects of antibody to tumor necrosis factor (TNF) in infection and sepsis. The authors tested whether bacteria type or treatment route alters antibody to TNF in a rat model of bacterial pneumonia. METHODS Rats (n = 231) received similarly lethal doses of either intratracheal Escherichia coli or Staphylococcus aureus followed by treatment with either...

It is possible to prepare from tubercle bacilli a fraction soluble in methanol which is capable of eliciting in mice a marked degree of resistance against virulent tuberculous infection. The immunity was evident whether the infective dose was large and caused a disease with a rapid course, or was very small and caused a disease of many months duration. Active material has been obtained by extra...

Sodium carboxy methyl cellulose (SCMC) is an important absorbable biomaterial for anti-adhesion and hemostasis medical devices used in the abdominal cavity. However, systemic toxicity of SCMC following intraperitoneal route has not been revealed sufficiently. Three solutions with gradient concentrations were intraperitoneally injected into 3 groups rats doses 50 mg/kg, 320 mg/kg 2000 respective...

The 4-day response of C3H/HeJ mice to sheep erythrocytes was suppressed by a lipid-free teichoic acid with an average molecular weight of 2,900 when it was administered by the intraperitoneal route. Enhancement was not observed at that time, and neither suppression nor enhancement could be demonstrated by the intravenous route. Either suppression or enhancement of background plaques could be in...