OBJECTIVE The purpose of this study was to estimate the T2* relaxation time in breast cancer, and to evaluate the association between the T2* value with clinical-imaging-pathological features of breast cancer. MATERIALS AND METHODS Between January 2011 and July 2013, 107 consecutive women with 107 breast cancers underwent multi-echo T2*-weighted imaging on a 3T clinical magnetic resonance ima...

The provasopressin protein (proAVP) is expressed by invasive breast cancer and non-invasive breast cancer, or ductal carcinoma in situ (DCIS). Here we demonstrate the ability of the monoclonal antibody MAG1 directed against the C-terminal end of proAVP to identify proAVP in all cases examined of human invasive cancer and DCIS (35 and 26, respectively). Tissues were chosen to represent a relevan...

Introduction Several studies indicate that ;50% of patients with positive biopsies for DCIS of the breast may develop invasive breast cancer within 1–24 years of diagnosis (1). The biological mechanisms involved in the progression of DCIS to invasive cancer are not fully understood. Although Ki67 labeling indices increased in invasive breast cancer (2, 3), there are limited data on this marker ...

BACKGROUND Protein kinase D1 is downregulated in its expression in invasive ductal carcinoma of the breast and in invasive breast cancer cells, but its functions in normal breast epithelial cells is largely unknown. The epithelial phenotype is maintained by cell-cell junctions formed by E-cadherin. In cancer cells loss of E-cadherin expression contributes to an invasive phenotype. This can be m...

Proteases give cancer a defining characteristic of being able to break through extracellular matrix barriers and invade into other tissues in response to chemotactic signals. Recently, the cell surface protease-activated receptor (PAR)-1 has been shown to act as a chemokine receptor in inflammatory cells, and its expression is tightly correlated with metastatic propensity of breast cancer cells...

Breast carcinogenesis results from the accumulation of numerous somatic genetic alterations. Although mutations of the tumor suppressor gene p53 are among the most common alterations identified in invasive breast carcinomas, it is not clear whether its alteration occurs frequently in non-invasive breast lesions, including usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH) and duc...

BACKGROUND Aldehyde dehydrogenase 1 (ALDH1) is an important marker of tumor-initiating cells. We aimed to investigate ALDH1 expression in benign breast disease and human breast cancer of different histologic stages. METHODS Immunohistochemical staining of ALDH1 was applied to 21 cases with benign breast diseases, 47 ductal carcinoma in situ (DCIS) cases, 62 cases diagnosed with invasive cance...

Breast cancer is one of the most common malignancies worldwide and is the second leading cause of cancer-related mortality among females. miRNAs are a class of small noncoding RNAs that are aberrantly expressed in human cancers. Due to their small size and stability, miRNAs have the potential to be efficacious clinical targets. MicroRNA-320a (miR-320a) has been shown to be dysregulated in multi...

Carcinoma of the breast has an unpredictable biological behav iour. Several oncogenes have. been im pli cated in the progression of breast cancer. Immunohistochemical staining of c-erb8-2 (Neu) oncoprotein and mutant p53 prote in on 45 cases of infil trating duct carcinoma (IDC) of the breast revealed 33% membrane positi vity of c-erb8-2 oncoprotein. 46% nuciear pos it ivity of mutated p53 prot...

We report two cases of invasive lobular carcinoma of the breast that were initially missed on first mammographic interpretation because of an uncommon, easily overlooked, and unreported imaging presentation. The abnormality in the cases manifested as an apparent decrease in breast glandular tissue volume when compared with the patients' previous mammograms, observed as "shrinking" of the breast...