In clinical research, questionnaires are an important tool available for population and large family studies to gather information on a patient’s medical history. In 1989, we described a large kindred of FrenchCanadian descent with an 8-fold increased risk of venous thrombosis due to the 3363C insertion in the protein C gene [1]. We developed a questionnaire for use in this family to assess gen...

A new score statistic is derived, which uses information from registries (age-specific incidences) and family studies (sib-sib marginal correlation) to weight affected sibling pairs according to their age at onset. Age at onset of sibling pairs is modelled by a gamma frailty model. From this model we derive a bivariate survival function, which depends on the marginal survival and on the margina...

We conducted a tuberculosis contact investigation for a female military recruit with an unreported history of multidrug-resistant tuberculosis (MDRTB) and subsequent recurrence. Pertinent issues included identification of likely contacts from separate training phases, uncertainty on latent MDRTB infection treatment regimens and side effects, and subsequent dispersal of the contacts after exposure.

Objective(s): Asthma, the most frequent chronic respiratory disease, results from a complex interaction between multiple genes and environmental factors. To date, more than 100 candidate genes and single nucleotide polymorphisms (SNPs) have been reported to be associated with asthma. One of the discovered genes related to asthma is ADAM33. However, the relationship between ADAM33 gene polymorph...

OBJECTIVE To investigate the mode of inheritance of ulcerative colitis and Crohn's disease by complex segregation analysis. DESIGN Cross sectional population based survey of familial occurrence of chronic inflammatory bowel disease. SETTING Population of the Copenhagen county in 1987. SUBJECTS 662 patients in whom inflammatory bowel disease had been diagnosed before 1979, of whom 637 (96%...

There are many grottoes of the Song and Jin Dynasties in northern Shaanxi, Qingliangshan Yan’an is typical representatives. Due to influence environmental geographical factors, microbial have caused surface weathering, pollution or discoloring cultural relics, as well potential dangers, which some damage grottoes. This paper based on investigation harmful samples Shaanxi Province. Using microsc...

enzyme electrophoresis was used to measure genetic variation within, and divergence among, three generations of recently bred synthetic alfalfa generations (syn1, syn2, and syn3) originating from a polycross of 12 selected parents and several cultivars. three isozyme loci, exhibiting tetrasomic inheritance in 10-day seedlings, were detected from five enzymatic systems analyzed by polyacryla...

It is generally recognized that there is a genetic component in the cleft lip and cleft palate malformation in man. There is good evidence that this malformation is heterogeneous, and that parts of it, for example isolated cleft palate compared with cleft lip with or without cleft palate, may have different genetic origins. The types of genetic mechanisms postulated for these defects have inclu...