A series of studies conducted 20 years ago, documenting the cardiac hypertrophy phenotype and its underlying signaling mechanism induced by angiotensin II (Ang II) and mechanical stress, showed a remarkable similarity between the effect of the Gαq agonist and that of mechanical forces on cardiac hypertrophy. Subsequent studies confirmed the involvement of autocrine/paracrine mechanisms, includi...

The complex-arithmetic performance of three different populations was tested: Flemish-speaking Belgians; Englishspeaking Canadians; and Chinese-speaking Chinese participants currently living in Canada. All participants solved complex addition problems (e.g., 58 + 73) under no-load and load conditions, in which one component of working memory (either the central executive or the phonological loo...

BACKGROUND Adrenaline auto-injectors (AAI) should be provided to individuals considered to be at high risk of anaphylaxis. There is some evidence that the rate of AAI prescription is increasing, but the true extent has not been previously quantified. AIM To estimate the trends in annual GP-issued prescriptions for AAI among UK children between 2000 and 2012. DESIGN AND SETTING Retrospective...

BACKGROUND Anaphylaxis is a medical emergency that requires the intramuscular injection of adrenaline using an adrenaline auto-injector (AAI). This study compared the robustness and performance characteristics of three AAIs available in Europe. METHODS Three AAIs (Jext(®), EpiPen(®), and Anapen(®)) were tested in terms of the force needed to activate the AAIs, exposed needle length, injection...

With the world's focus on reducing the leprosy patient load to the extent of elimination, finding and reporting the rarer presentations of leprosy becomes important for prompt treatment. Also, these untreated patients may serve as a potential source of infection in community. We report a 35-year old man diagnosed to have lepromatous leprosy and erythema nodosum leprosum with inguinal lymph node...

BACKGROUND A study was undertaken to investigate the pathogenesis of pulmonary involvement in human T lymphotropic virus type I (HTLV-I) carriers. METHODS The bronchoalveolar lavage (BAL) cell profile of 30 HTLV-I carriers (15 asymptomatic HTLV-I carriers (AHCs) and 15 symptomatic HTLV-I carriers (SHCs)) with chronic inflammatory diseases of respiratory tract and eight patients with HTLV-I as...

As technology develops, the prevalence of conventional book dictionaries has slowly declined due to advancements in computer-mediated aids, such as online type-in dictionaries and program-installed pop-up aids. The goal of this study was to examine how technology ‘‘may” have changed the long-standing pedagogical practice of book dictionary usage by identifying the learning processes associated ...

The regulatory pathways involved in the rapid response of the AP-1 transcription factor, c-fos, to mechanical load in human primary osteoblast-like (HOB) cells and the human MG-63 bone cell line were investigated using a four-point bending model. HOB and MG-63 cells showed upregulation of c-fos expression on fibronectin and collagen type I substrates; however, MG-63 cells did not respond on lam...