21 Iodine is a key component of the thyroid hormones which are crucial for brain development. 22 Pregnant women are vulnerable to iodine deficiency because their requirement for iodine is 23 higher than that of non-pregnant adults. Data on the iodine status of UK pregnant women are 24 sparse and there are no such data in the South East. One hundred pregnant women were recruited 25 to a cross-se...

We studied two sisters who developed large non-toxic goitres in adolescence. Deiodinase deficiency was diagnosed by a rapid thyroid uptake of radioactive iodine (RAI) at 2 hours associated with a marked fall in thyroidal 131I by 24 hours. Serial RAI scans in the second patient documented evolution of the iodine-deficient state. Conservation of intra-thyroidal iodine stores was maintained by avi...

Objective: To screen pregnant women for micronutrient deficiency specially iodine and iron deficiency during early pregnancy. Methods: Pregnant women (≤ 16 weeks) attending antenatal clinic in Hi-Tech medical college and hospital were enrolled for the study. Urine and blood samples were collected from 300 pregnant women for estimation of urinary iodine, haemoglobin and thyroid hormones. Results...

Iodine is an essential micronutrient incorporated into thyroid hormones. Although iodine deficiency can lead to a broad spectrum of disorders throughout life, it is most critical in the early stages of development, as the foetal brain is extremely dependent on iodine supply. During the last two decades, our understanding of thyroid physiology during gestation has substantially improved. Further...

OBJECTIVE To determine the magnitude of goitre in school children and measure indicators of iodine deficiency including the most commonly consumed staple foods. DESIGN A cross-sectional study. SETTING Ten villages from four administrative regions of Ethiopia. SUBJECTS A total of 2485 randomly selected elementary school children were examined for clinical signs of goitre. Indicators of iod...

BACKGROUND Iodine deficiency is a major public health problem throughout Africa. Although salt for human consumption is said to contain adequate amounts of iodine in Uganda, iodine intake may not be optimal. We undertook a field study to assess the adequacy of iodine nutrition in western Uganda using on-site measurement methods of neonatal thyroid stimulating hormone (TSH) levels as recommended...

Many millions of people throughout the world are at risk of developing iodine deficiency-associated disorders. The underlying effects of iodine deficiency on neuroendocrine function are poorly defined. We have studied stress-induced and diurnal variation in corticosterone secretion in female rats rendered chronically hypothyroid by feeding them an iodine-free diet for 6 months. Corticosterone s...

BACKGROUND As a component of thyroid hormones, iodine is essential for fetal brain development. Although the UK has long been considered iodine replete, increasing evidence suggests that it might now be mildly iodine deficient. We assessed whether mild iodine deficiency during early pregnancy was associated with an adverse effect on child cognitive development. METHODS We analysed mother-chil...

OBJECTIVE Denmark was an area of iodine deficiency, and mandatory iodine fortification of table salt and salt in bread (13 p.p.m. iodine) was initiated in 2000/2001. The Danish investigation on iodine intake and thyroid disease (DanThyr) is the monitoring of the iodine fortification program. DESIGN AND METHODS DanThyr consists of three main parts: a study of population cohorts initialized bef...