The aggregation of shape-persistent macrocycles with an empty cavity, an undecyldiether strand and a tetraethylene glycol strand leads in all cases to a macroscopic gelation of the solvent. However, the gelation temperatures are fine-tuned by the intraannular substituents.

high purity fluorapatite (FA) with rod-like and spherical-like morphology was synthesized via sol-gel method. Chemical characterization of FA powders was done by XRD and FTIR analyses. Crystallite samples were calculated using Scherer method. Morphology of FA powders was investigated with TEM and SEM images. The results revealed that increasing the time of hydrolysis of phosphate sols significa...

Purpose: To create a skin delivery system based on chitosan-tripolyphosphate nanoparticles (cs-tpp np) for acyclovir with enhanced chemical stability and satisfying permeation through skin. Methods: Cs-tpp np were prepared based on ionotropic gelation between positively charged amino groups of cs and negatively charged tpp as previously reported by Krauland et al. [1] with different amounts of ...

The synthesis of pectin-silica gels for controlled drug release in gastrointestinal tract (GIT) using low methoxyl (LM) and high methoxy (HM) pectins and tetraethoxysilane (TEOS) as precursor is described. The FTIR spectra of the pectin-silica gels show intense absorption bands at 1246cm-1 and 802cm-1 corresponding to the vibrations COSi bonds, which absent in the FTIR spectra of the native pec...

The widespread emergence of antibiotic-resistant bacteria has highlighted the urgent need of alternative therapeutic approaches for human and animal health. Targeting virulence factors that are controlled by bacterial quorum sensing (QS), seems a promising approach. The aims of this study were to generate novel nanoparticles (NPs) composed of chitosan (CS), sulfo-butyl-ether-β-cyclodextrin (Cap...

PURPOSE Gene therapy offers a promising alternative for the treatment of ocular diseases. However, the implementation of this type of therapy is actually hampered by the lack of an efficient ocular gene delivery carrier. The main objective of the present work was to assess the effectiveness and investigate the mechanism of action of a new type of nanoparticle made of two bioadhesive polysacchar...

Chitosan coated alginate microcapsules were developed as oral sustained delivery carriers for anti tubercular drugs in order to improve patient compliance, to reduce dose/dosing frequency in the management of tuberculosis (TB), which otherwise demands prolonged chemotherapy. Alginate–chitosan microparticles encapsulating three frontline anti-tuberculosis drugs (ATDs), rifampicin, isoniazide and...

Nitrofurazone (NTZ) is usually employed in the topical treatment of infected wounds and lesions of both skin and mucosa. Microencapsulation is a process utilized in the incorporation of active ingredients within polymers aiming at, among other objectives, the prolonged release of pharmaceutical compounds and protection from atmospheric agents (viz. moisture, light, heat and/or oxidation). With ...

BACKGROUND AND THE PURPOSE OF THE STUDY Pectin derivatives have been utilized for colonic drug delivery (CDD). In this study the effects of different formulation variables upon the characteristics of pectinate microparticles (MPs) prepared by ionotropic gelation technique for colonic delivery of mesalazine was investigated. METHODS In-vitro drug release of MPs was studied using USP XXIV disso...