Purpose: To report four cases of toxic anterior segment syndrome after cataract surgery under intracameral 0.5% lidocaine anesthesia.Case summary: Four patients had a decrease in visual acuity within 3 days undergoing surgery. There was evidence chamber inflammation with corneal edema and opacity. Toxic diagnosed on the basis negative microbial cultures clinical features. Three were treated sys...

Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells affected by radiation to cause the GI syndrome are derived from the epithelium or endothelium and whether the target cells die by apoptosis or other mechanisms are controversial issues. Studying mouse models, we found that selective deleti...

Severe acute respiratory syndrome coronavirus 2, the causative virus of disease 2019, causes thrombosis via direct effects on vascular endothelial cells. Necrosis extremities due to arterial occlusion has been reported in patients with 2019. Here, we report a case multiple occlusions associated Although extent which severe 2 infection is responsible for development necrosis this patient uncerta...

BACKGROUND Several studies suggest that cardiovascular risk factors comprising the metabolic syndrome have larger effects on the development of cardiovascular disease in women than in men. A recent study in self-reported healthy subjects demonstrated a marked gender difference in endothelial dysfunction that may be an important precursor of manifest cardiovascular disease. The aim of the presen...

Up to 30% of patients with chest pain who undergo coronary arteriography, have completely normal coronary angiograms. The subgroup with typical angina and a positive response to stress testing is generally included under the diagnosis of cardiovascular syndrome X. Several causes and mechanisms have been investigated in the past twenty years, to explain both chest pain and ischemic angina-like S...

Background: The burden of cataract and glaucoma has been increasing. Primary angle closure occurs as a result crowded anterior segment anatomy causing appositional contact between peripheral iris trabecular meshwork. Lens extraction proposed method deepening chamber managing intraocular pressure. Purpose: To assess changes in depth after phacoemulsification with lens implantation narrow eyes. D...

Citation: da Costa RM, Silva JFd, Alves JV, Dias TB, Rassi DM, Garcia LV, Lobato NdS and Tostes RC (2018) Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises the Anti-contractile Properties of Perivascular Adipose Tissue in Metabolic Syndrome. Front. Physiol. 9:341. doi: 10.3389/fphys.2018.00341 Increased O-GlcNAcylation of Endothelial Nitric Oxide Synthase Compromises th...

Sir—Liappis et al. [1] noted decreased mortality rates among bacteremic patients who were receiving statins, but they were not able to define the mechanisms by which this reduction in the mortality rate occurred. It has recently been proposed that endothelial apoptosis could be the pivotal event in the pathogenesis of systemic inflammatory response syndrome, sepsis, acute respiratory distress s...

Acute respiratory distress syndrome is an inflammatory disease characterized by dysfunction of pulmonary epithelial and capillary endothelial cells, infiltration of alveolar macrophages and neutrophils, cell apoptosis, necroptosis, NETosis, and fibrosis. Inflammatory responses have key effects on every phase of acute respiratory distress syndrome. The severe inflammatory cascades impaired the re...

DESCRIPTION Coronary slow flow (CSF) is a phenomenon characterised by delayed opacification of coronary arteries in the absence of epicardial stenosis, in which microvascular and endothelial dysfunction have been implicated in pathophysiology. The association between acute coronary syndromes (ACS) and Behcet’s syndrome is well known but rare, and is especially important due to the tendency to a...