Friedreich ataxia is caused by reduced activity of frataxin, a conserved iron-binding protein of the mitochondrial matrix, thought to supply iron for formation of Fe-S clusters on the scaffold protein Isu. Frataxin binds Isu in an iron-dependent manner in vitro. However, the biological relevance of this interaction and whether in vivo the interaction between frataxin and Isu is mediated by adap...

The opportunistic pathogen Pseudomonas aeruginosa forms biofilms, which render it more resistant to antimicrobial agents. Levels of iron in excess of what is required for planktonic growth have been shown to promote biofilm formation, and therapies that interfere with ferric iron [Fe(III)] uptake combined with antibiotics may help treat P. aeruginosa infections. However, use of these therapies ...

The title compound, [Fe(NO)(2)(C(21)H(21)P)(2)], belongs to the family of metal dinitrosyl compounds with the general formula Fe(NO)(2)(L)(x), referred to collectively as 'dinitrosyl iron compounds' (DNICs). Herein we report the structure of a dinitrosyl iron diphosphane complex, [Fe(NO)(2)L(2)], with L = P(C(6)H(4)-p-CH(3))(3). There are two crystallographically independent but chemically equa...

Mono and bis hexamethylenetetramine iron(III) chloride, Fe(N C ,H ) CI (I) and Fe(N C ,H ) Cl (II) were synthesized by the reaction of iron(III) chloride and hexamethylenetetramine (HMTA) in chloroform. Chemical analysis and spectral results show the coordination of HMTA to the iron(III). Electronic transition spectra of compound I and I1 were also studied in coordinating and noncoordinatin...

Improved methods for studying intracellular reactive Fe(II) are of significant interest for studies of iron metabolism and disease-relevant changes in iron homeostasis. Here we describe a highly selective reactivity-based probe in which a Fenton-type reaction with intracellular labile Fe(II) leads to unmasking of the aminonucleoside puromycin. Puromycin leaves a permanent and dose-dependent mar...

The electrodeposition of iron and Zn-Fe alloys on polycrystalline nickel was investigated in the 40.0-60.0 mol % zinc chloride1-ethyl-3-methylimidazolium chloride ionic liquid containing iron~II! at 90°C. Iron~II! was electrochemically reduced to iron metal before the reduction of zinc~II! to zinc metal, and anomalous codeposition of Zn-Fe did not occur in this ionic liquid. Underpotential depo...

The title compound, [Fe(NO)(2)(C(18)H(12)F(3)P)(2)]·CHCl(3), belongs to the family of metal dinitrosyl compounds with the general formula Fe(NO)(2)(L)(x), referred to collectively as 'dinitrosyl iron compounds' (DNICs). Herein we report the structure of a dinitrosyl iron diphosphane complex, (Fe(NO)(2)L(2), with L = P(C(6)H(4)-p-F)(3). The structure includes one metal complex mol-ecule and one ...

Mononuclear nonheme iron(IV)-oxo complexes with two different topologies, cis-α-[Fe(IV)(O)(BQCN)](2+) and cis-β-[Fe(IV)(O)(BQCN)](2+), were synthesized and characterized with various spectroscopic methods. The effect of ligand topology on the reactivities of nonheme iron(IV)-oxo complexes was investigated in C-H bond activation and oxygen atom-transfer reactions; cis-α-[Fe(IV)(O)(BQCN)](2+) was...

Reduction of Fe(3+) to Fe(2+) is a prerequisite for Fe uptake by tomato roots. Ferric chelate reductase activity in plasma membranes (PM) isolated from roots of both iron-sufficient (+Fe) and iron-deficient (-Fe) tomatoes (Lycopersicon esculentum Mill.) was measured as NADH-dependent ferric citrate reductase and exhibited simple Michaelis-Menten kinetics for the substrates, NADH and Fe(3+)(citr...

The new biomimetic ligands N4Py(2Ph) (1) and N4Py(2Ph,amide) (2) were synthesized and yield the iron(II) complexes [Fe(II)(N4Py(2Ph))(NCCH3)](BF4)2 (3) and [Fe(II)(N4Py(2Ph,amide))](BF4)2 (5). Controlled orientation of the Ph substituents in 3 leads to facile triplet spin reactivity for a putative Fe(IV)(O) intermediate, resulting in rapid arene hydroxylation. Addition of a peripheral amide sub...