Introduction: Irreversible electroporation (IRE) is a process in which the membrane of the cancer cells are irreversibly damaged with the use of high-intensity electric pulses, which in turn leads to cell death. The IRE is a non-thermal way to ablate the cancer cells. This process relies on the distribution of the electric field, which affects the pulse amplitude, width, and electrical conducti...

The movement of ions through the cell membrane is in the literature and in textbooks explained by the action of protein ion channels. An exception is the field of electroporation. Electroporation is a temporary reversible electrical breakdown induced by lipid channels in the membrane. The lipid channels are caused by large trans membrane voltages, hence the pore models of electroporation are no...

BACKGROUND Radiofrequency ablation inside pulmonary vein (PV) ostia can cause PV stenosis. A novel alternative method of ablation is irreversible electroporation, but the long-term response of PVs to electroporation ablation is unknown. METHODS AND RESULTS In ten 6-month-old pigs (60-75 kg), the response of PVs to circular electroporation and radiofrequency ablation was compared. Ten consecut...

The combination of Irreversible Electroporation and Electrochemotherapy (IRECT) was well tolerated, safe, and had antitumor activity in this case study of a patient with lymph node metastases from gastric cancer. We therefore recommend the consideration of further clinical studies to investigate the treatment of cancerous tissue with IRECT.

Electroporation, is known to induce cell membrane permeabilization in the reversible (RE) mode and cell death in the irreversible (IRE) mode. Using an experimental system designed to produce a continuum of IRE followed by RE around a single electrode we used MRI to study the effects of electroporation on the brain. Fifty-four rats were injected with Gd-DOTA and treated with a G25 electrode impl...

Cholangiocarcinoma (CCA) is an invasive cancer accounting for <1% of all cancers and 10–15% primary liver cancers. Intrahepatic CCA (iCCA) associated with poor survival rates high post-surgical recurrence whilst most diagnosed patients are not surgical candidates. There a growing literature suggesting percutaneous ablative techniques the management iCCA measuring ≤3 cm contraindications to s...