نتایج جستجو برای: irs2
تعداد نتایج: 621 فیلتر نتایج به سال:
The production of red blood cells is tightly regulated by erythropoietin (Epo). The phosphoinositide 3-kinase (PI 3-kinase) pathway was previously shown to be activated in response to Epo. We studied the role of this pathway in the control of Epo-induced survival and proliferation of primary human erythroid progenitors. We show that phosphoinositide 3 (PI 3)-kinase associates with 4 tyrosine-ph...
We present molecular line, H 2 O maser, radio continuum and near infrared maps of the bipolar outtow source AFGL 5142. The high resolution of our molecular CO observations enables us to deene the morphology of the large-scale bipolar outtow into a two lobe structure extending for 2 0 on each side of the center. In the perpendicular direction, we nd consistent evidence for a second, more compact...
BACKGROUND Insulin resistance has been linked with colorectal neoplasia through a number of mechanistic and observational studies. Allelic variants of genes encoding components of the insulin pathway, including insulin (INS), insulin receptor (INSR), and insulin receptor substrate-1 and insulin receptor substrate-2 (IRS1 and IRS2) have been associated with hyperinsulinemia and insulin resistanc...
Homeobox genes play a critical role in embryonic development, but they have also been implicated in cancer through mechanisms that are largely unknown. While not expressed during normal T-cell development, homeobox transcription factor genes can be reactivated via recurrent chromosomal rearrangements in human T-cell acute leukemia/lymphoma (T-ALL), a malignancy often associated with activated N...
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