Functional mitral regurgitation (MR) is one of the major contributing factors for heart failure and hospitalization in both nonischemic and ischemic dilated cardiomyopathy. The limitation of undersized mitral annuloplasty has been recognized. Recurrent late MR is associated with continued left ventricular (LV) remodeling and enhanced papillary muscle displacement outside posterior ring after mi...

Background Global myocardial edema, a surrogate measure of myocardial inflammation, has been reported in patients with chronic dilated cardiomyopathy (DCM) based on T2weighted STIR imaging. However, STIR imaging is prone to motion artefact and issues related to cardiac cycle timing and coil sensitivity. We hypothesised that a novel quantitative CMR T2 mapping technique would provide a reliable ...

Pegylated interferon alpha (Peg IFN-α) in combination with ribavirin is the backbone of treatment in chronic hepatitis C (CHC). Cardiotoxicity due to interferon therapy is rare. The most frequent cardiovascular complications are arrhythmias and ischemic manifestations. Cardiomyopathy is extremely rare but can be life threatening. We present the case of a 41-year-old female patient with CHC in w...

control of unmappable ventricular tachycardia in patients with ischemic and nonischemic cardiomyopathy. Circulation 2000;101:1288–96. 6. Josephson ME, Waxman HL, Cain ME, et al. Ventricular activation during ventricular endocardial pacing. II. Role of pace-mapping to localize origin of ventricular tachycardia. Am J Cardiol 1982;50:11–22. 7. Leclercq C, Faris O, Tunin R, et al. Systolic improvem...

We present here a case of end-stage non-ischemic valvular dilated cardiomyopathy (DCM) associated with mitral regurgitation (MR). The patient underwent surgery where left ventricular volume reduction using endoventricular circular patch plasty (EVCPP) and mitral valve replacement (MVR) were performed. He has improved much after the operation and is now in New York Heart Association (NYHA) funct...

BACKGROUND The anti-ischemic agent trimetazidine improves ejection fraction in heart failure that is hypothetically linked to inhibitory effects on cardiac free fatty acid (FFA) oxidation. However, FFA oxidation remains unmeasured in humans. We investigated the effects of trimetazidine on cardiac perfusion, efficiency of work, and FFA oxidation in idiopathic dilated cardiomyopathy. METHODS AN...

beta-blocker treatment in patients with advanced heart failure. Effects on neurohormones. Int J Cardiol 2000; 73: 7–12. [7] Effects of metoprolol CR in patients with ischemic and dilated cardiomyopathy: the randomized evaluation of strategies for left ventricular dysfunction pilot study. Circulation 2000; 101: 378–84. [8] Cice G, Tagliamonte E, Ferrara L, Iacono A. Efficacy of carvedilol on com...

The patient is a 68-year-old man who had heterotopic heart transplantation (HHTx) performed 8 years ago for ischemic dilated cardiomyopathy. The patient presented for noninvasive evaluation of transplant cardiac function and patency of anastomotic connections. A contrast-enhanced 3Dmagnetic resonance angiogram (MRA) was performed, and the data reconstructed using a 3D volume-rendering technique...

A 56-year-old man with ischemic dilated cardiomyopathy underwent a secondary prevention biventricular implantable cardioverter defibrillator (ICD) implant. He did not respond symptomatically despite a good radiographic position of the left ventricular (LV) lead. On the basis of an acute hemodynamic study, a second LV lead was implanted, resulting in a good clinical response from dual-site LV pa...

Background Several small studies have suggested that left atrial enddiastolic volume (LAEDV) is associated with adverse outcomes in patients with non-ischemic dilated cardiomyopathy (NICM). However, left atrial function, assessed through either LA end-systolic volume (LAESV) or the LA ejection fraction (LAEF) may provide incremental predictive utility. We sought to evaluate the prognostic value...