A single injection of isoproterenol results, after a lag period of 20 hours, in a marked stimulation of DNA synthesis and cell proliferation in the mouse salivary gland. The incorporation of leucine-3H into three acidic nuclear protein fractions (nonhistone nuclear proteins) increases within 30 min following the administration of isoproterenol and does not return to control levels until 48 hour...

The beta-adrenergic agonist isoproterenol stimulates immunoreactive atrial natriuretic peptide (IR-ANP) secretion by superfused rat atria in vitro. beta-Adrenergic agonists alter the cellular handling of calcium, which culminates in a rise in the systolic calcium concentration. This is achieved by increasing calcium influx through voltage-dependent calcium channels and by increasing the storage...

cAMP content and protein phosphorylation were determined in unlabeled and 32P-labeled guinea pig ventricular myocytes. Isoproterenol (10 nM, 37 degrees C, 10 seconds) increased cAMP content (236%) and phospholamban (265%) and troponin I (135%) phosphorylation in ventricular myocytes. When isoproterenol (0-300 nM) and the A1-adenosine receptor agonist (-)-N6-phenylisopropyladenosine (PIA, 1 micr...

OBJECTIVES We sought to determine whether the relationship between heart rate (HR) and QT interval (QT) differs as HR increases in response to exercise, atropine and isoproterenol. BACKGROUND Autonomic nervous system influences on repolarization are poorly understood and may complicate the interpretation of QT measurements. METHODS Twenty-five normal subjects sequentially underwent graded-i...

Adenylate cyclase in turkey erythrocyte membranes is activated only slowly by guanylyl-8,y-imidodiphosphate (GPP(NH)P) in the absence of isoproterenol but is responsive to fluoride. Incubation of membranes with isoproterenol and GMP allows subsequent isoproterenol-independent stimulation by GPP(NH)P and causes a decline in fluoride-stimulated enzyme activity. The decrement in fluoride activatio...

Changes in contractility and the levels of adenosine 3':5'-cyclic monophosphoric acid (cAMP) were assessed in isolated cat cardiac muscle in response to soluble isoproterenol and isoproterenol immobilized on glass beads. Drug-induced positive inotropic responses were compared to the maximum isometric force achieved with paired electrical stimulation, a potent physiological inotropic stimulus. I...

A microdissected rabbit intrarenal arterial glomeruli (glomerulectomy) , but with variability between experiments. An even higher infusion network (IAN) perfused at constant flow with rate of isoproterenol (11 mg/min) in Group 2 Krebs-bicarbonate solution was employed to caused no significant AII release. Similarly, in determine whether this network, which has a high Group 3, in which a longer ...

UNLABELLED Heart rate (HR) response to IV atropine is attenuated during propofol-nitrous oxide (N(2)O) anesthesia. We studied the effects of propofol-N(2)O anesthesia on isoproterenol-induced HR changes. The control group (n = 15) received no propofol and no N(2)O. Patients in the propofol-N(2)O group (n = 21) received IV propofol 2.5 mg/kg over 1 min followed by a continuous infusion of propof...

Various lymphocyte populations have been studied for their content in cyclic adenosine 3',5'-monophosphate (cAMP) before and after stimulation by isoproterenol and prostaglandin E(1) (PGE(1)). Basal cAMP levels vary among lymphocytes according to their origin: peripheral blood lymphocytes show high cAMP level while spleen and lymph node cells and thymocytes show lower levels. Thymocytes are ext...

The incidence of myocardial infarction was found to be high among people of Indian origin who are living abroad. Disease of coronary artery is almost always due to atheroma and its complications. It is predicted that heart disease and stroke will become one of the leading causes of death and disability worldwide by the year 2020. The Materials And Methods were All Wistar strain male albino rats...