The involvement of catecholamines in stress-induced heart injury is well documented. However, the contribution of adrenergic receptor types is less understood. Both the profile of plasma marker enzyme activities (lactate dehydrogenase-1 and aspartate transaminase) and the distribution and morphology of the lesions observed in tissue sections of adrenaline-injected mice resembled those of stress...

The interaction of the renin-angiotensin system and the sympathetic nervous system in patients with congestive heart failure is not well understood. We tested the hypothesis that angiotensinconverting enzyme inhibitors can resensitize the fJ-adrenergic receptor system. Guinea pigs were given captopril, isoproterenol, or both for 2 weeks. At death, cardiac sarcolemmal and light vesicle fractions...

The effects of isoproterenol, norepinephrine, dobutamine, exercise, and nitroglycerin on left ventricular diameter, pressure, velocity of shortening, dP/dt, dP/dt/P, arterial pressure, left circumflex coronary blood flow, and coronary vascular resistance were examined in healthy conscious dogs with normal coronary perfusion and in the same animals after moderate global ischemia had been induced...

The properties of adenosine inhibition of catecholamine-induced responses were investigated, using an isolated rat heart preparation. Perfusion of hearts with 0.1 microM isoproterenol increased myocardial cAMP content 2.8-fold, activation of cAMP-dependent protein kinase 4.4-fold, phosphorylase a formation 3.4-fold, left ventricular pressure 1.8-fold, rate of ventricular pressure development 2....

Sustained high levels of circulating catecholamines may induce cardiotoxicity through oxidative mechanisms. Isoproterenol is a synthetic catecholamine with increasing attention owing to this application in cardiology. The aim of the present study was to investigate the cardioprotective effects of Vitis vinifera seed against isoproterenolinduced myocardial ischemia. Normal Wistar strain rats wer...

Saini, Harjot K., Onkar N. Tripathi, Shetuan Zhang, Vijayan Elimban, and Naranjan S. Dhalla. Involvement of Na /Ca exchanger in catecholamine-induced increase in intracellular calcium in cardiomyocytes. Am J Physiol Heart Circ Physiol 290: H373–H380, 2006. First published September 9, 2005; doi:10.1152/ajpheart.00613.2005.—Although sarcolemmal (SL) Na /Ca exchanger is known to regulate the intr...

during a period of four years between june, is, 1988 to june, is, 1992 one hundred and fourteen patients with congestive heart failure (chf) were admitted to the pediatric department of taleghani general hospital. during the above period, 192 patients with heart disease were hospitalized at this department and chf was the cause of admission in 59.4% of them. congenital heart disease (cho) was t...