A standardized bioassay previously developed with ivermectin for the yellow dung fly (Scathophagidae) and the face fly (Muscidae) was applied to test the response of 11 dung fly species to the presumably less toxic parasiticide moxidectin. The results were compared to existing data for the same species tested with ivermectin, albeit two new species (Scathophaga suilla and Musca domestica) were ...

larvae and surgical debridement, in conjunction with ivermectin and systemic broad-spectrum antimicrobial drugs to prevent secondary infections (1,2). Treatment with ivermectin can kill the larvae (1; references 14,15 in the online Technical Appendix) and result in considerable reduction of larvae in infested wounds. Ivermectin has a broad antiparasitic spectrum that causes immobilization of pa...

The effect of ivermectin, a new microfilaricide, was assessed in a double blind trial against diethylcarbamazine citrate (DEC) and placebo. Fifty-nine adult males with moderate to heavy infection with Onchocerca volvulus and with eye involvement were recruited from an area under Onchocerciasis Control Programme (OCP) vector control in Northern Ghana. They were randomly assigned to an eight-day ...

BACKGROUND Onchocerciasis can be effectively controlled by annual mass treatment with ivermectin in endemic communities. However, in communities that are endemic for loiasis there may be significant risk of severe adverse reactions after ivermectin treatment. Planning of control requires therefore mapping of these two infections using rapid assessment tools developed for each disease. These too...

Ivermectin is a veterinary pharmaceutical generally used to control the ecto- and endoparasites of livestock, but its use has resulted in adverse effects on coprophilous insects, causing population decline and biodiversity loss. There is currently no information regarding the direct effects of ivermectin on dung beetle physiology and behaviour. Here, based on electroantennography and spontaneou...

The impact of a school health club on adult perception of onchocerciasis and compliance with ivermectin was evaluated in an onchocerciasis-endemic community in southeastern Nigeria. Venous blood was collected from each of 26, 32 and 124 randomly selected subjects during ivermectin distribution programmes in 1995 1996 and 1997 respectively. Ivermectin concentrations were measured in the samples....

Throughout the battle against SARS-CoV-2 (COVID-19), various medications have been repurposed in hopes of finding a successful treatment modality to combat global pandemic. One medication that has recently begun show promising advancement clinical trials is well-known anti-parasitic medication, ivermectin. In this review, we delve into ivermectin and its use as therapeutic agent COVID-19. The f...

BACKGROUND When a severe peritonitis outbreak in semi-domesticated reindeer was noticed in 2003 in Finland, the concerned industry urged immediate preventive actions in order to avoid detrimental effects of S. tundra and further economical losses. A research programme was swiftly initiated to study S. tundra and its impact on the health and wellbeing of reindeer. METHODS The ultimate aim of t...

AIM To establish the prevalence of anthelmintic resistance in parasitic nematodes on sheep farms in New Zealand. METHODS A cross-sectional prevalence study was conducted, using a standardised faecal nematode egg count (FEC) reduction (FECR) test (FECRT) for ivermectin, at a full (0.2 mg/kg) and half (0.1 mg/kg) dose rate, and albendazole, levamisole and albendazole-levamisole in combination, ...

BACKGROUND Avermectin and milbemycin are important 16-membered macrolides that have been widely used as pesticides in agriculture. However, the wide use of these pesticides inevitably causes serious drug resistance, it is therefore imperative to develop new avermectin and milbemycin analogs. The biosynthetic gene clusters of avermectin and milbemycin have been identified and the biosynthetic pa...