Both germline transcription and switch recombination of heavy chain genes are likely to be regulated by cis elements binding transcription factors in the promoter regions of germline immunoglobulin genes. To identify cis-acting elements important in germline transcription of the murine c1 heavy chain gene, we have used a transgenic approach. Seventeen kb c1 immunoglobulin transgenes with mutati...

This study aimed to identify gastric mucosal protectants that suppress intestinal tumorigenesis in a mouse model. We chose six gastric mucosal protectants (ecabet sodium hydrate, irsogladine maleate, rebamipide, sofalcone, teprenone and troxipide) and examined their effects on the activity of oxidative stress-related transcriptional factors, including AP-1, NF-jB, NRF2, p53 and STAT3, in Caco-2...

The testing of high-dimensional normality is an important issue and has been intensively studied in the literature, it depends on variance–covariance matrix sample numerous methods have proposed to reduce its complexity. Principle component analysis (PCA) widely used high dimensions, since can project data into a lower-dimensional orthogonal space. reduced then be evaluated by Jarque–Bera (JB) ...

Definition 19. A generalized complex structure (GCS) on E is an integrable orthogonal complex structure J : E E, i.e. a map s.t. → • �JA, JB� = �A,B� • L = Ker (J − i1) Note. 1. �JA,B� = �JA, JB� = −�A, JB�, and thus �J·, ·� is a symplectic struction on E compatible with �, �. 2. L is maximal isotropic and so is L, and thus E = L ⊕ L = L ⊕ L∗ and we get a Lie bialgebroid. 3. V must be even dime...

Two types of cytochrome P450 2D14 (CYP2D14) gene deletions (GD1 and GD2) in Japanese Black cattle has been reported by us. In this study, we determined the frequency of cytochrome P450 2D14 (CYP2D14) genetic polymorphisms in 48 Japanese Black (JB) and 48 Holstein-Friesian (HF) cattle using polymerase chain reaction (PCR)-direct sequencing. Two types of CYP2D14 gene deletion variants, GD1 and GD...

Let M and N be two unital JB∗-algebras let U(M) U(N) denote the sets of all unitaries in N, respectively. We prove that following statements are equivalent: isometrically isomorphic as (complex) Banach spaces;M real spaces;there exists a surjective isometry Δ:U(M)→U(N).We actually establish more general statement asserting that, under some mild extra conditions, for each Δ:U(M)→U(N), we can fin...

We introduce the “sample” technique to generate robust critical values for the Jarque and Bera (JB) Lagrangian Multiplier (LM) test for normality, JBCV( 1 2 , k k ), by using improved critical values the true size of the test approaches its nominal value. Monte Carlo methods are used to study the size, and the power of the JB normality test with the “sample” critical values and compare with thr...

The B cell hybridomas producing monoclonal antibodies (E10, D7, F4, H6, and D4) were established by the fusion of P3U1 or NS-1 murine myeloma cell lines and spleen cells of B10.A(5R) mice hyperimmunized with mitomycin C-treated B10.A(3R) spleen and thymus cells. Two types of monoclonal antibodies specific for the products controlled by a gene in the I-Jb subregion of the H-2 complex were charac...