1. To study further the influence of luminal nutrition on small bowel structure and function, segments of rat jejunum and ileum were completely excluded from intestinal continuity by Thiry-Vella by-pass operations. The effect of partial deprivation of luminal nutrition was also studied in jejunal segments that had been surgically transposed to a distal position in the intestinal tract. 2. Macro...

Using mice deficient in hepatic cytochrome P-450 oxidoreductase (POR), which disables the liver cytochrome P-450 system, we examined the metabolism and biological response of the anticarcinogenic flavonoid, quercetin. Profiling circulating metabolites revealed similar profiles over 72 h in wild-type (WT) and POR-null (KO) mice, showing that hepatic P450 and reduced biliary secretion do not affe...

Intestinal monosaccharide transport was studied in a series of rats with a self-filling jejunal blind loop using 3mM arbutin (p-hydroxyphenyl-B-glucoside) or 1mM D-fructose as substrate in vitro and 10 mM arbutin or 5mM D-fructose in vivo. These results were compared with changes in the bacterial flora and state of conjugation of intraluminal bile salts in those animals. Observations were also ...

The effects of dietary calcium (Ca) concentration on the digestion of Ca, phosphorus (P), nitrogen (N), fat and starch along the intestinal tract of broilers were assessed. Three-week old broilers were fed maize-soy diets containing 6, 9 or 12 g/kg of Ca (Ca: total P ratios of 1:1, 1.4:1 and 2:1, respectively) for six days and digesta were collected from the duodenum, jejunum, upper ileum and l...

Ileocecal resection (ICR) is a commonly required surgical intervention in unmanageable Crohn's disease and necrotizing enterocolitis. However, the impact of ICR, and the concomitant doses of antibiotic routinely given with ICR, on the intestinal commensal microbiota has not been determined. In this study, wild-type C57BL6 mice were subjected to ICR and concomitant single intraperitoneal antibio...

The adipocyte hormone leptin activates signal transducer and activator of transcription 3 (STAT3) in the hypothalamus, mediating increased satiety and increased energy expenditure. To date, leptin-mediated activation of the STAT pathway in vivo has not been established in tissues other than hypothalamus. We now describe leptin receptor expression and in vivo signaling in discrete regions of the...

Incomplete intestinal obstruction due to windsock web of the jejunum is uncommonly noticed in neonates. We present a male neonate, prenatally suspected case of proximal bowel obstruction, who was found to have features of incomplete intestinal obstruction due to windsock deformity in jejunum. The difficulty in the diagnosis and management is discussed along with relevant literature review.

Multiple diverticulosis of the jejunum is an uncommon pathology small bowel. The incidence diverticulum intestine varies from 0.3 to 1.2%, out which duodenal diverticula are common that jejunal. This rare jejunal usually asymptomatic in course, made it more difficult establishing this diagnosis. may rarely lead complications such as perforation, haemorrhage, obstruction be due adhesions, volvul...