These are consistent with proposals that Fgf10 expression in the developing sensory tissues is required to induce non-sensory development. To determine the otic epithelial functions of Fgf3 and Fgf10, we generated double conditional mutants using TgPax2Cre, and found that as expected, both genes play roles in semicircular canal morphogenesis. Unexpectedly, these genes also appear to have redund...

Over several decades genetic studies have unraveled many molecular mechanisms that underlie the signaling networks guiding morphogenesis, but the mechanical forces at work remain much less well understood. Accumulation of fluid within a luminal space can generate outward hydrostatic pressure capable of shaping morphogenesis at several scales, ranging from individual organs to the entire vertebr...

We address the problem of cell segmentation in confocal microscopy membrane volumes of the ascidian Ciona used in the study of morphogenesis. The primary challenges are non-uniform and patchy membrane staining and faint spurious boundaries from other organelles (e.g. nuclei). Traditional segmentation methods incorrectly attach to faint boundaries producing spurious edges. To address this proble...

Little is known about the regulatory signals involved in tendon and ligament formation, and this lack of understanding has hindered attempts to develop biologically based therapies for tendon and ligament repair. Here we report that growth and differentiation factors (GDFs) 5, 6, and 7, members of the TGFb gene superfamily that are most related to the bone morphogenetic proteins, induce neotend...

The cerebellum has a unique morphology characterized by fine folds called folia. During cerebellar morphogenesis, folia formation (foliation) proceeds with granule cell (GC) proliferation in an external granular layer, and subsequent migration to internal layer (IGL). GC is guided along Bergmann glial (BG) fibers, whose orientation depends on the deformation of tissue during formation. aim this...

Investigated the histological features of structure hepar one-day-old lambs (ODL) using a complex morphological techniques. It was found that in ODL is formed by stroma and parenchyma. The stromal elements organ are loose lugs hematopoietic connective tissue, which turn forms capsule (2.80-7.23 microns thick), as well septa lobules, include triads paravasal tissue efferent blood vessels. As res...

background: there is little information about blood supply of the carpal joint in one- humped camel, while there is extensive data about cow and equine species. in order to perform surgeries and diagnostic techniques in carpal region, information about the elements of the joint such as its arteries is necessary. objectives: this study aims at describing the origins, arrangements, and branches o...

extending and retracting numerous actin-rich protrusions during tubule morphogenesis. Interestingly, tubule morphogenesis fails in mutant embryos lacking tip cells and supports a role for tip cells during this phase of tubule development. Moreover, the tip cells make highly specific contacts with target tissues once tubule morphogenesis is complete and these persist during larval life, raising ...

Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial-mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators o...