With 82 species currently described, the genus <i>Leptodactylus</i> is most diverse and representative one in family Leptodactylidae. Concerning chromosomal organization, this represents an interesting underexplored group since data from molecular cytogenetics are incipient, little known about organization distribution of repetitive DNA elements karyotypes. In sense, study aimed at ...

We analyzed cytogenetically 105 patients with hypocellular primary MDS and their clinical implications. The main chromosomal abnormalities found were del(5q)/-5, del(6q)/+6, del(7q)/-7, del(11q), and del(17p). Pediatric patients had a higher frequency of abnormal karyotypes compared with adult patients (P < 0,05). From our patients, 18% showed evolution of the disease. The chromosomal abnormali...

We studied the relationship of direct karyotypes, determined at diagnosis and remission, to Abelson-related tyrosine kinase activity and the cytogenetic features of erythroid and myeloid colonies derived from remission marrow of six children with acute lymphoblastic leukemia (ALL). These patients had either the characteristic Philadelphia chromosome (Ph1) [t(9;22)(q34;q11)] or cytogenetically s...

Morphological and chromosomal characteristics of a number of unionid freshwater mussels were studied from northeastern Thailand. Karyotypes of eight species from seven genera (Chamberlainia, Ensidens, Hyriopsis, Physunio, Pseudodon, Scabies and Trapezoideus) were examined. Six species possess 2n = 38 karyotypes, whereas Scabiescrispata and an unidentified Scabies sp. lack three small chromosome...

Up to 20% of patients with polycythemia vera have karyotypic abnormalities at the time of the initial diagnosis. However, the cytogenetic abnormalities in polycythemia vera have not been well characterized and their prognostic impact is largely unknown. In this study, we aimed to address these issues using a large cohort of polycythemia vera patients with cytogenetic information available. The ...

The histolÃ3gica! pleomorphism of human malignant gliomas as well as their variable response to therapy suggests that such tumors are not homogeneous but are composed of a hetero geneous population of cells. To search for heterogeneity in these tumors, we developed a protocol to identify by karyotype, isolate, and clone the subpopulations of the tumor. Freshly resected tumors were mechanically ...