The authors describe one case of squamouscell carcinoma of the liver, which developed in a 54-year-old male. The gross tumor was a cyst, 10 cm in diameter, with the brown contents. A histological study revealed high-grade differentiated squamous-cell carcinoma without keratinization. An immunohistochemical study showed a positive reaction with cytokeratin 19 and PCNA expression in single nuclei...

Proliferating trichilemmal tumor (PTT) is an uncommon neoplasm arising from the follicular isthmus. Its histological characteristic is the presence of trichilemmal keratinization. PTT usually presents as a solitary nodule on the scalp of elderly women. We describe a case of a PTT on the gluteal region (buttocks) of a 16-year-old female, presenting as a solitary nodule.

Background: Psoriasis is a common and chronic inflammatory skin disease that has profound adverse effects on patients’ wellbeing. Trace elements are essential to biochemical processes in the body and are involved in immunological and inflammatory reactions such as keratinization and melanin formation. The aim of this study was to evaluate the essential metals in psoriasis in comparision with he...

A 5-year-old female, known case of pachyonychia congenita, presented with diffuse hair loss; remaining hairs were easily plucked kinky hairs. Hair samples from patient were investigated using a light microscope. The hairs of the patients were mainly anagen hairs and unlike normal plucked anagen hairs, showed keratinization and cornification of their hair bulbs. No specific hair shaft abnormalit...

UNLABELLED Histological staging of deep invasive margin of oral squamous cell carcinoma has a significant influence on survival of patients since the tumor cells are more poorly differentiated in this area and have high prognostic value. AIM The purpose of the present study is to correlate TNM clinical classification with histopathologic characteristics (degree of keratinization, nuclear pleo...

The corneal epithelium is the outermost layer of the cornea that directly faces the outside environment, hence it plays a critical barrier function. Previously, conditional loss of Notch1 on the ocular surface was found to cause inflammation and keratinization of the corneal epithelium. This was in part attributed to impaired vitamin A metabolism, loss of the meibomian glands and recurrent eyel...

Palmoplantar keratoderma (PPK) is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of the palms and soles. There are three clinical patterns: diffuse, focal, and punctuate. Palmoplantar keratodermas can be divided into the following functional subgroups: disturbed gene functions in structural proteins (keratins), cornified envelope (loricrin, trans...