Metabolites of the kynurenine pathway (KP) of tryptophan (TRP) degradation have been closely linked to the pathogenesis of several neurodegenerative disorders. Recent work has highlighted the therapeutic potential of inhibiting two critical regulatory enzymes in this pathway-kynurenine-3-monooxygenase (KMO) and tryptophan-2,3-dioxygenase (TDO). Much evidence indicates that the efficacy of KMO i...

Users are inclined to share sensitive data in a remote server if no strong security mechanism is in place. Searchable encryption satisfies the need of users to execute a search on encrypted data. Previous searchable encryption method such as “public key encryption with keyword search (PEKS)” restricted the data access to certain users, because only the assigned users were able to search on the ...

The design of effective indicators and indicator systems requires a profound understanding of the relevant business context. Numerous relations and dependencies within an indicator system exist, which need to be analysed thoroughly: Many relations are based on implicit assumptions or sometimes not known by the management at all. This is of particular relevance for business success, since improp...

BACKGROUND An important role for synovial pathology in the initiation and progression of knee osteoarthritis has been emphasised recently. This study aimed to examine whether ultrasonography-detected synovial changes associate with knee pain (KP) in a community population. METHODS A case-control study was conducted to compare people with early KP (n = 298), established KP (n = 100) or no KP (...

The present work addresses the case study of a national trading company through the Knapsack Problem (KP). This logistic problem consists on determining the products to be stored that have the best cost-benefit ratio for the company without affecting its storage capacity. This is the reason why the KP a binary multi-criterion problem of NP-hard complexity. While there are exact tools that can s...

Regarding to rapidly changing and highly competitive business environment it will become increasingly important for organizations to measure their performances appropriately. With respect to special characteristics of pharmaceutical industry and lack of reported performance measurement, this study tries to design an integrated performance measurement model for pharmaceutical companies. For gene...

Abstract Steers (n = 192; initial shrunk BW 446 ± 28.3 kgs) were used in a 112-d finishing experiment Treatments arranged 2 x factorial (24 pens total; 8 steers/pen) to evaluate corn silage moisture [1/2 2/3 milk line (ML) and black (BL)] kernel processing at harvest on steer growth performance carcass traits. blocked by batch fraction 6) pen as the experimental unit. The model included effects...

It is shown that products of eigenfunctions and (integrated) adjoint eigenfunctions associated with the (modiied) Kadomtsev-Petviashvili (KP) hierarchy form generators of a symmetry transformation. Linear integro-diierential representations for these symmetries are found. For special cases the corresponding nonlinear equations are the compatibility conditions of linear scattering problems of Lo...

BACKGROUND Klebsiella pneumoniae (KP) expressing hypermucoviscosity phenotype (HV-KP) has abundant capsular polysaccharide (CPS) and is capable of causing invasive syndrome. Sodium salicylate (SAL) reduces the production of CPS. The study was aimed to investigate the relationship between aspirin usage and KP-mediated invasive syndrome and the effect of SAL on HV-KP. METHODS Patients with comm...