Sensory hair cell (HC) loss is a major cause of permanent hearing and balance impairments for humans and other mammals. Yet, fish, amphibians, reptiles, and birds readily replace HCs and recover from such sensory deficits. It is unknown what prevents replacement in mammals, but cell replacement capacity declines contemporaneously with massive postnatal thickening of F-actin bands at the junctio...

Albuminuria is a strong, independent predictor of chronic kidney disease progression. We hypothesize that podocyte processing of albumin via the lysosome may be an important determinant of podocyte injury and loss. A human urine derived podocyte-like epithelial cell (HUPEC) line was used for in vitro experiments. Albumin uptake was quantified by Western blot after loading HUPECs with fluorescei...

The antioxidant activity of aqueous extracts of fresh leaves of costmary (Chrysanthemum balsamita L.) was investigated. The effect of the extraction time on total phenolic compounds (TPhC) and antioxidant activity (ABTS -, CUPRACand FRAP assays) was studied. Results demonstrated highest levels of TPhC (0.60 GAE/g fresh plant weight), CUPRAC (5.93 μMTE/g FW), ABTS (10.68 μMTE/g FW), and FRAP (7....

background and objectives:alzheimer’s disease (ad) is a neurodegenerative disorder. nowadays, many investigations are performed to find new drugs for ad and medicinal plants are considered as one of the most important sources for developing new drugs. according to the role of oxidant agents and acetylcholinesterase enzyme (ache) in ad, plants with antioxidant and ache inhibition properties coul...

background and objectives:lallemantia iberica (lamiaceae) is a medicinal plant distributed in different parts of iran. this research, has evaluated the phytochemical constituents and antioxidant activity of the aerial parts of the plant. methods: different chromatographic methods such as column chromatographies using silica gel (normal and reversed phases), sephadex lh-20 and hplc were used for...

Syzygium polyanthum is traditionally used as anti-hypertensive. However, the nephroprotective effects of S. against hypertensive induced chronic kidney disease remains to be done. This study was conducted determine antioxidant properties and aqueous extract (AESP) in spontaneous rat model (SHR). The phytochemical constituent identified using screening HPLC methods. vitro activities were determi...