نتایج جستجو برای: kidney injury molecule 1

تعداد نتایج: 3210891  

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Kyung Pyo Kang Duk Hoon Kim Yu Jin Jung Ae Sin Lee Sik Lee Sang Yong Lee Kyu Yun Jang Mi Jeong Sung Sung Kwang Park Won Kim

BACKGROUND Cisplatin is a chemotherapeutic agent used in treatment of malignant tumours. However, cisplatin produces various side effects, such as nephrotoxicity, neurotoxicity, emetogenesis and ototoxicity. Inflammation is an important mechanism of cisplatin nephrotoxicity. Alpha-lipoic acid (alpha-LA) has anti-inflammatory effects that inhibit both adhesion molecule expression in human endoth...

2017
Hongzhou Meng Guanghou Fu Jie Shen Kezhen Shen Zhijie Xu Yiming Wang Baiye Jin Hao Pan

Oxidative stress and inflammation are part and parcel of cisplatin-induced nephrotoxicity. The purpose of this work is to study the role of soy isoflavone constituent, daidzein, in cisplatin-induced renal damage. Cisplatin-induced nephrotoxicity was evident by the histological damage in proximal tubular cells and by the increase in serum neutrophil gelatinase-associated lipocalin (NGAL), blood ...

2008
Aleksandar Gavrić Jurij Matija Kališnik

BACKGROUND Acute kidney injury (AKI) is a common and serious problem in critically ill patients. Tests currently used to detect AKI (i.e., serum creatinine, serum urea and various urinary indices) often result in serious delays in detection of clinically relevant injury. This delayed detection translates into a potential missed opportunity for therapeutic interventions at a time when kidney dam...

Journal: :Consilium medicum 2023

In recent years, the attention of scientists has been actively focused on studying role endocan as a biological marker endothelial dysfunction in cardiovascular diseases. Until studied acute kidney injury, chronic disease, and renal replacement therapy. Endocan, formerly known cell-specific molecule-1, is soluble dermatan sulfate proteoglycan expressed secreted into circulation from cells. Curr...

Journal: :American journal of physiology. Renal physiology 2011
Istvan Arany Samira Grifoni Jeb S Clark Eva Csongradi Christine Maric Luis A Juncos

Recent epidemiological reports showed that smoking has a negative impact on renal function and elevates the renal risk not only in the renal patient but perhaps also in the healthy population. Studies suggested that nicotine, a major tobacco alkaloid, links smoking to renal dysfunction. While several studies showed that smoking/chronic nicotine exposure exacerbates the progression of chronic re...

2014
Xu Zeng Deloar Hossain David G Bostwick Guillermo A Herrera Ping L Zhang

Objective. After filtration through glomeruli, β2-microglobulin is reabsorbed in proximal tubules. Increased urinary β2-microglobulin indicates proximal tubule injury and measurement of β2-microglobulin in urine is useful to determine the source of renal injury. Kidney injury molecule-1 (KIM-1) has been characterized as a selective proximal tubule injury marker. This study was designed to evalu...

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