Ethylene glycol (CAS RN 107-21-1) can cause kidney toxicity via the formation of calcium oxalate crystals in a variety of species, including humans. Numerous repeated dose studies conducted in rats have indicated that male rats are more susceptible than female rats. Furthermore, subchronic and chronic studies using different dietary exposure regimens have indicated that male Wistar rats may be ...

BACKGROUND/AIMS Interferon treatment of malignant or viral diseases can be accompanied by various side-effects including nephro-toxicity. METHODS We report on a 68-year-old Caucasian male who received dual therapy with pegylated interferon 2a plus ribavirin for chronic hepatitis C. RESULTS After three months of antiviral therapy, the patient developed acute kidney failure (serum creatinine ...

Cadmium (Cd) is an environmental toxicant of widespread exposure and pervasive toxicity. Absorption, systemic transport and uptake of Cd are mediated by metal transporters that the body uses for acquisition of physiologically-essential elements, notably of iron, zinc and calcium. Currently, human exposure to Cd is known to damage the kidneys, especially the proximal tubular cells that actively ...

Thimerosal is an ethyl mercury-containing compound used mainly in vaccines as a bactericide. Although the kidney is a key target for mercury toxicity, thimerosal nephrotoxicity has not received the same attention as other mercury species. The aim of this study was to determine the potential cytotoxic mechanisms of thimerosal on human kidney cells. Human kidney proximal tubular epithelial (HK2) ...

to assess toxicity in control and selenium-deficient rats given paraquat and diquat. Lipid peroxidation was measured by determining ethane production rates of intact animals; toxicity was assessed by survival and by histological and serum enzyme evidence of liver and kidney necrosis. Paraquat and diquat were both much more toxic to selenium-deficient rats than to control rats. Diquat (19.5 umol...

The liver, kidney, and thyroid glands are main vital in biochemical physiological activities animals humans. In this study, we examined the effects of adding selenium supplementation on improvement activity many such as after cadmium chloride administration (induced toxicity) male rabbits. This study included 16 rabbits divided into four groups, 1st group (CON) was control normal fed drinking w...

Cadmium (Cd) is an environmental hazardous heavy metal that causes renal dysfunction triggered by its toxicity to proximal tubular cells. Our previous study demonstrated Cd changed the activities of various transcription factors (TFs) in mouse kidney. In this study, we investigated whether long-term exposure affected expression levels downstream genes these TFs. C57BL/6J female mice were fed ch...

objectives: mangifera indica (mango) is used in folk medicine for treatment of different types of diseases, and its anti-inflammatory and free radical scavenging activities have been demonstrated. the present study evaluated the effects of commercial (vimang) and hydroalcoholic extract of mango on gentamicin-induced nephrotoxicity in rat. materials and methods: female wistar rats were treated w...