Correspondence to: Prof. Brunello Wüthrich, Allergy Unit, Department of Dermatology, University Hospital Zurich, Gloriastrasse 31 CH–8091 Zurich (Switzerland) Dear Sir, We read with interest the letter by Yamada et al. [1]. Our experience is in contrast with the results of the Japanese colleagues. In fact, we have published in the January 1994 issue of Allergy [2] that the measurement of solubl...

Th2-driven responses are instrumental in disease processes including allergies, asthma, and helminth infection, and are characterized by the production of the cytokines IL-4, IL-5, IL-9, and IL-13. These cytokines form a complex network of molecular and cellular interactions that mediate protective immunity not only to worm infection, but also to induce inappropriate inflammatory responses to a...

Thrombosis and ELISA optical density values in hospitalized patients with heparin-induced thrombocytopenia. from patients with heparin-induced thrombocytopenia/ thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells. Validation of the high-heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia. No significant improvement in di...

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NK cells preferentially recognize and kill cells that lack expression of MHC class I (1). While inhibitory receptors expressing immunoreceptor tyrosine-based inhibition motifs prevent NK cells from harming tissues expressing normal levels of classical or nonclassical MHC class I (for a review , see reference 2), what turns on NK cells? Recent reports (3, 4), including Smith et al. in this issue...

Psoriasis is an inflammatory skin disease with accelerated epidermal cell turnover. Neutrophil accumulation in the skin is one of the histological characteristics of psoriasis. However, the precise mechanism and role of neutrophil infiltration remain largely unknown. In this article, we show that orchestrated action of CXCR2 and leukotriene B 4 receptor BLT1 plays a key role in neutrophil recru...

ost conventional media depend on engaging and appealing characters. Empty spaces and buildings would not fare well as television or movie programming, yet virtual reality usually offers up such spaces. The problem lies in the difficulty of creating computer-generated characters that display real-time, engaging interaction and realistic motion. Articulated figure motion for real-time computer gr...

What is it about movement in cells that commands our atten-tion? What biologist has not enjoyed turning a microscope on a cell, almost any cell, really, and watching all the commo-tion? When vesicles, mitochondria, chloroplasts, nuclei, or chromosomes move, we are being treated to an elegant, easily observable manifestation of molecular events. Decades of effort to understand intracellular move...

485 Naive T cells race around lymph nodes in search of their specific antigens but, according to a study on page < A r t R e f v o l = " 2 0 3 " I s s = " 3 " > < A r t R e f v o l = " 2 0 3 " I s s = " 3 " > 619< / A r t R e f > < / A r t R e f > , natural killer (NK) cells are in less of a hurry. Bajénoff and colleagues provide the first glimpse of NK cells in live lymph nodes, revealing slow...

interests are in the elds of robotics and machine learning, including dextrous manipulation, teleoperation, autonomous mobile robots and adaptive robot behavior. LEARNING DEXTROUS MANIPULATION SKILLS 15 Heuristics derived form observations made on human hands were used to reduce the degrees of freedom of dextrous manipulation with robotic hands. This signiicantly simpliied the task and made aut...