We compare several methods for sensitivity analysis of differential–algebraic equations (DAEs). Computational complexity, efficiency and numerical conditioning issues are discussed. Numerical results for a chemical kinetics problem arising in model reduction are presented.  2000 IMACS. Published by Elsevier Science B.V. All rights reserved.

Traditionally, models are generated building on macroscopic field theory substituting as much of the transformations as possible with the aim to generate models of sets of ordinary differential equations when ever possible. Today, computer programs are available solving Differential Algebraic Equations (DAEs) efficiently rendering most of the algebraic substitutions unnecessary. Our Modeller to...

A computer model was developed for the estimation of the kinetics of microbial inactivation by pulsed electric field (PEF). The model is based on the electroporation theory of individual membrane damage, where spherical cell geometry and distribution of cell sizes are assumed. The variation of microbial cell sizes was assumed to follow a statistical probability distribution of the Gaussian type...

Inulosucrases catalyze transfer of a fructose moiety from sucrose to a water molecule (hydrolysis) or to an acceptor molecule (transferase), yielding inulin. Bacterial inulin production is rare and a biochemical analysis of inulosucrase enzymes has not been reported. Here we report biochemical characteristics of a purified recombinant inulosucrase enzyme from Lactobacillus reuteri. It displayed...

Acid dissociation constant (pKa) of some para-substituted benzohydroxamic, 4-XC6H4CONHOH, and N-methyl parasubstituted benzohydroxamic acids, 4XC6H4CON(OH)CH3, where X = H, CH3, CH3O, NO2, Cl, have been determined spectrophotometrically by nucleophilic substitution reactions of pnitrophenyl acetate with hydroxamate ions at 27± 0.1C. All reactions in this study follow pseudo-first order kinetics...

We demonstrate an approach to automatically generating kinetic models of metabolic networks. In a first step, the metabolic network is characterised by its stoichiometric structure. Then to each reaction a kinetic equation is associated describing the metabolic flux. For the kinetics we use a formula that is universally applicable to reactions with arbitrary numbers of substrates and products. ...

Thermogravimetric studies of chitin and chitosan in air atmosphere were carried out at six rates of linear increase of the temperature. The kinetics and mechanism of the thermal decomposition reaction were evaluated from the TG data using recommended from ICTAC kinetics committee isoconversional calculation procedure of Kissinger-Akahira-Sunose, as well as 27 mechanism functions. The values of ...