We have asked whether loss of the Ca2+ sensor protein synaptotagmin I influences the total amount of neurotransmitter released after a presynaptic action potential. Hippocampal neurons from synaptotagmin I knock-out mice had a greatly reduced fast synchronous component of glutamate release, as reported previously. However, the amount of glutamate released during the slow asynchronous component ...

The Auxin Binding Protein 1 (ABP1) is one of the most studied proteins in plants. Since decades ago, it has been the prime receptor candidate for the plant hormone auxin with a plethora of described functions in auxin signaling and development. The developmental importance of ABP1 has recently been questioned by identification of Arabidopsis thaliana abp1 knock-out alleles that show no obvious ...

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Knock is an undesirable event that causes most of the abnormal combustion in spark ignition (SI) engines. In this paper, a novel knock intensity diagnosis method for SI engines by vibration analysis based on the ensemble empirical mode decomposition (EEMD) is proposed. First, the vibration signal measured from the test SI engine cylinder head is decomposed by the EEMD. Because the EEMD can elim...

Transgenic animals have become important tools for the production of therapeutic proteins in the domestic animal. Production efficiencies of transgenic animals by conventional methods as microinjection and retrovirus vector methods are low, and the foreign gene expression levels are also low because of their random integration in the host genome. In this study, we investigated the homologous re...

Knock research is an essential study because knock limits spark-ignition (SI) engine power output, durability, noise, fuel consumption, and emission performance. The thermal efficiency of can be improved by increasing the compression ratio, but at same time it leads to possibility end gas autoignition inside chamber. objective this work was show effect three different ratios (CRs) 8.5, 9.5, 10....

We analyze the two-player game of Knock ’em Down, asymptotically as the number of tokens to be knocked down becomes large. Optimal play requires mixed strategies with deviations of order √ n from the naive law-of-large numbers allocation.

(Cell Reports 33, 108456-1–108456-8.e1–e5; December 1, 2020) In the originally published version of this article, Eran Elhaik was incorrectly spelled in author list. The corrected list appears here and with article online. authors regret error. Rare Variant Burden Analysis within Enhancers Identifies CAV1 as an ALS Risk GeneCooper-Knock et al.Cell ReportsDecember 01, 2020In BriefCooper-Knock al...

Deleterious processes of extracellular proteolysis may contribute to the progression of tissue damage after acute brain injury. We recently showed that matrix metalloproteinase-9 (MMP-9) knock-out mice were protected against ischemic and traumatic brain injury. In this study, we examined the mechanisms involved by focusing on relevant MMP-9 substrates in blood-brain barrier, matrix, and white m...