Leontidine and camoensine, the main representatives of small quinolizidine-indolizidine alkaloid subgroup, are characterized by an inner bispidine system to which a 2-pyridone pyrrolidine fused on opposite sides. We efficiently synthesized both natural products from commercially available abundant cytisine, was converted into key intermediate, N-Boc-11-oxocytisine, iodine oxidation protection. ...

A method for the description of spin-isospin phase transitions in nuclear matter is developed. It aliows a complete description of the pion condensation phase transition in the framework of the Landau-Migdal Fermi liquid theory. The equation of the order Parameter is derived and the condensation energy is calculated. We study the influence of pion condensation on the nuclear equation of state a...

Last years several experiments were performed, which studied the Bose-Einstein condensation of quasi-particles, in particular, magnons in magnetically ordered systems. Recently the Bose-Einstein condensation of magnons was observed at room temperatures in a ferromagnetic film. The theory of the condensation (re-distribution) of magnons under the conditions of pumping, which explains many featur...

Our attention was called to the use of picrolonic acid in precipitating alkaloids and we have studied its behavior with some of the more important representatives of this group. Like picric acid picrolonic acid precipitates many basic nitrogen compounds and, since the latter has given better results in other instances, we thought it advisable to determine the relative value of these reagents as...

In Alzheimer’s disease (AD) two aberrant proteins amyloid plaques (Aβ) and Neurofibrillary tangles (NFTs) have been identified. Aβ peptide is produced from soluble amyloid precursor protein (SAPP) as a result of two sequential proteolysis steps by β-secretase [beta-site Amyloid Precursor Protein Cleaving Enzyme (BACE)] then γ-secretase. NFTs, are made up of several proteins but primarily hypoph...

We present a forcing to obtain a localized version of Local Club Condensation, a generalized Condensation principle introduced by Sy Friedman and the first author in [3] and [5]. This forcing will have properties nicer than the forcings to obtain this localized version that could be derived from the forcings presented in either [3] or [5]. We also strongly simplify the related proofs provided i...

Akt promotes cell survival by phosphorylating and inhibiting components of the intrinsic cell death machinery. Akt translocates into the nucleus upon exposure of cells to survival factors, but little is known about its functions in the nucleus. Here, we show that acinus, a nuclear factor required for apoptotic chromatin condensation, is a direct target of Akt. We demonstrate that Akt phosphoryl...

We report the development of a new method for producing mitotic extracts from tissue culture cells. These extracts reproducibly promote the condensation of chromatin in vitro when incubated with purified interphase nuclei. This condensation reaction is not species specific, since nuclei from chicken, human, and hamster cell lines all undergo chromatin condensation upon incubation with the extra...

We report the development of a new method for producing mitotic extracts from tissue culture cells. These extracts reproducibly promote the condensation of chromatin in vitro when incubated with purified interphase nuclei. This condensation reaction is not species specific, since nuclei from chicken, human, and hamster cell lines all undergo chromatin condensation upon incubation with the extra...

The Condensation and the Wavelet Approximated Reduced Vector Machine (W-RVM) approach are joined by the core idea to spend only as much as necessary effort for easy to discriminate regions (Condensation) and measurement locations (W-RVM) of the feature space, but most for regions and locations with high statistical likelihood to contain the object of interest. We unify both approaches by adapti...