Primary myelofibrosis (PMF) and polycythaemia vera (PV) are rare BCR-ABL1-negative myeloproliferative neoplasms, associated with an increased risk of thrombosis, haemorrhagic complications progression to fibrosis or leukaemia for PV. Both diseases characterised by biological clinical heterogeneity, leading great variability in their management routine practice. In this review, we present update...

Much medical education is concerned with principles of disease diagnosis and treatment. Much medical research is, as a result, concerned to inform those principles with new understanding about the causes and mechanisms of disease and how best to reach a diagnosis and prescribe effective treatments linked to the diagnosis.[1] Primary care education seeks to develop expertise in understanding the...

Background and Aim: Oral squamous cell carcinoma (OSCC) accounts for approximately 3% of all cancers worldwide, and if diagnosed early, it has a five-year survival rate of around 85%; however, a late diagnosis may decrease the survival rate to 50%. Aberrant expression of several genes is associated with the hallmarks of OSCC including uncontrolled cell proliferation, poor differentiation, invas...

primary retroperitoneal mucinous tumor (prmt) of low malignant potential (border line) is an uncommon neoplasm with fewer than 50 reported cases. uncertain diagnostic imaging results make diagnosis of its origin difficult, preoperatively. later treatment planning and prognosis would be affected by exact diagnosis of the tumor origin. this study presents a case of persian woman with diagnostic, ...

BACKGROUND: The technical developments of imaging methods over the last 2 decades are changing our knowledge of perinatal oncology. Fetal ultrasound is usually the first imaging method used and thus constitutes the reference prenatal study, but MRI seems to be an excellent complementary method for evaluating the fetus. The widespread use of both techniques has increased the diagnosis rates of c...

Glioblastoma multiform(GBM) is the most prevalent primary brain tumor. Exosomes are extracellular vehicles for exchanging information between various cell types including cancer and normal cells. Exosomes are indicative of pathophysiological conditions of brain tumors that could be used in diagnosis and prognosis of GBM. In tumors, exosomes could carry various molecules like several miRNAs and ...

Abstract The politics of knowledge matter to the current wave de-democratization in Europe. Building on Walby’s social complexity theory, this article highlights dynamics between epistemic configurations and contemporary politics. Focusing academic institutions, taking gender studies as an illustration, shows that actors opposing (social) sciences academia not only aim dismantle existing instit...