نتایج جستجو برای: l asparaginase
تعداد نتایج: 619728 فیلتر نتایج به سال:
Production, Purification and Kinetic Characterization of L-asparaginase from Pseudomonas Fluorescens
Objective: L-asparaginase has been isolated from a wide variety of microbial as well as plant and animal sources. In the study the production, partial purification and kinetic characterization of L-asparaginase from Pseudomonas fluorescens were carried. Methods: L-asparaginase was produced by submerged fermentation method. The purification of L-asparaginase was done through ammonium sulphate pr...
L-Asparaginase inhibits the growth of several animal and human tumors and delays the onset of mitotic activity that occurs in the residual liver following 70% hepatectomy. In the present study the effect of this agent upon DNA synthesis in Morris hepatomas of varying growth rates was determined. A single, small dose of L-asparaginase produced a prolonged inhibition of a very-slow-growing tumor,...
Introduction: The use of L-asparaginase as a chemotherapeutic agent is an effective strategy for the treatment of leukemic lymphoblasts. Since the use of bacterial L-asparaginase causes side effects due to hypersensitivity reactions, search for new enzyme sources is one of the active research areas. In this study, the characterization of produced L-asparaginase by indigenous yeast strains was i...
SUMMARY The effect of L-asparaginase on imm'unosuppression in mice was studied with procedures measuring the ability to produce circulating antibodies against sheep erythrocytes and allogeneic tumor cells and the'incidence of tumor take in the allogeneic mice. The production of anti-sheep erythocyte antibodies on primary immune response in C57BL/Na X A/Jax F1 mice was markedly suppressed at a d...
A survey of 109 recently derived leukemias of the mouse revealed that sensitivity to suppression by guinea pig serum is a common property of transplanted leukemias of certain classes. The sensitive leukemias included five that arose spontaneously in mice of strains with a low incidence of leukemia and 21 that were induced by X-radiation. Two GPS-sensitive leukemias were not more sensitive than ...
We designed a new treatment protocol incorporating concurrent administration of L-asparaginase (to reduce the probability of systemic progression during concurrent chemoradiotherapy (CCRT)) plus high-dose methotrexate to consolidation chemotherapy to intensify the regimen for treating localized extranodal NK/T cell lymphoma, nasal type (ENKTL). CCRT comprised radiation (36-44 Gy) with weekly ci...
Resistance to L-asparaginase in leukemic cells may be caused by an elevated cellular expression of asparagine synthetase (AS). Previously, we reported that high AS expression did not correlate to L-asparaginase resistance in TEL-AML1-positive B-lineage acute lymphoblastic leukemia (ALL). In the present study we confirmed this finding in TEL-AML1-positive patients (n = 28) using microarrays. In ...
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