Safe, effective, orally delivered, live adenovirus vaccines have been in use for three decades. Recombinant derivatives of the live adenovirus vaccines may prove an economical alternative to current vaccines for a variety of diseases. To explore that possibility, we constructed a series of recombinants that express the major capsid protein (L1) of canine oral papillomavirus (COPV), a model for ...

Testicular germ cell tumor (GCT) is the most common malignancy in young males between the ages of 15 to 35 years. Although the overall cure rate of GCTs approaches 95%, almost 25% of patients with distant metastases die from the cancer. Active investigations on novel treatment options for platinum-refractory GCTs include immunotherapies such as program-death 1 (PD-1)/program death-ligand 1 (PD-...

Malignant tumor cells are equipped with mechanisms that can help them escape the surveillance by host immune system. Immune checkpoint molecules can transduce coinhibitory signals to immunocompetent cells and exert immunosuppressive roles in antitumor immunity. Programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) are the two important checkpoint molecules with great potential in targ...

Many image denoising methods can be characterized as minimizing “loss + penalty,” where the “loss” measures the fidelity of the denoised image to the data, and the “penalty” measures the smoothness of the denoising function. In this paper, we propose two models that use the L1-norm of the pixel updates as the penalty. The L1-norm penalty has the advantage of changing only the noisy pixels, whil...

High-risk human papillomavirus (HPV) is the primary cause of cervical carcinoma (CC). Viral integration into the host chromosomes is associated with neoplastic progression, and epigenetic changes may occur as a result. The objective of the present study was to analyze HPV L1 gene methylation and to compare the use of quantitative polymerase chain reaction (qPCR), in situ hybridization (ISH) and...

The Initiation-Response-Feedback (IRF) cycle (teachers’ initiation, students’ response and teachers’ feedback) has been a key focus in studies of second language classroom interaction and participation. This paper aims to examine the influence of the first language (L1) in the Initiation-Response-Feedback (IRF) cycle commonly appearing in teacher-fronted classroom interaction. Previous studies ...

Immunotherapy based on blockade of the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) axis has shown promising clinical activity for renal cell carcinoma (RCC) patients; however, the most effective use of these agents in combination with conventional targeted therapy remains to be resolved. Here we evaluated the therapeutic efficacy of the combination of the mTOR inhibitor everolim...

Our goal is to predict the first language (L1) of English essays’s authors with the help of the TOEFL11 corpus where L1, prompts (topics) and proficiency levels are provided. Thus we approach this task as a classification task employing machine learning methods. Out of key concepts of machine learning, we focus on feature engineering. We design features across all the L1 languages not making us...

We study the L1-error estimates for the upwind scheme to the linear advection equations with a piecewise constant coefficients modeling linear waves crossing interfaces. Here the interface condition is immersed into the upwind scheme. We prove that, for initial data with a bounded variation, the numerical solution of the immersed interface upwind scheme converges in L1-norm to the differential ...