We present an easy-to-use, open-source Optimised Exome analysis tool, OpEx (http://icr.ac.uk/opex) that accurately detects small-scale variation, including indels, to clinical standards. We evaluated OpEx performance with an experimentally validated dataset (the ICR142 NGS validation series), a large 1000 exome dataset (the ICR1000 UK exome series), and a clinical proband-parent trio dataset. T...

OBJECTIVE To investigate the effects of laboratory testing policies, particularly selective testing, rule-based reporting and isolate identification, on estimates of community antimicrobial resistance. MATERIALS AND METHODS Antibiotic resistance estimates were analysed from an all-Wales dataset for approximately 300 000 community isolates of common pathogens. RESULTS Selective testing polic...

The cancer Biomedical Informatics Grid (caBIG) was launched in 2003 by the US National Cancer Institute with the aim of connecting research teams through the use of shared infrastructure and software to collect, analyse and share data. It was an ambitious project, and the issue it aimed to address was huge and far-reaching. With such developments as the mapping of the human genome and the advan...

Patients who were previously treated for prostate cancer with radiation therapy are monitored at regular intervals using a laboratory test called Prostate Specific Antigen (PSA). If the value of the PSA test starts to rise, this is an indication that the prostate cancer is more likely to recur, and the patient may wish to initiate new treatments. Such patients could be helped in making medical ...

The dataset includes data from the electroencephalogram study reported in our paper: 'Effects of simulated interpersonal touch and trait intrinsic motivation on the error-related negativity' (doi:10.1016/j.neulet.2016.01.044) (Tjew-A-Sin et al., 2016) [1]. The data was collected at the psychology laboratories at the Vrije Universiteit Amsterdam in 2012 among a Dutch-speaking student sample. The...

We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using ...

Wind induced ovalling vibrations were observed during a storm in October 2002 on several empty silos of a closely spaced group consisting of 8 by 5 thin-walled silos in the port of Antwerp (Belgium). In the present study, it is investigated if the observed ovalling oscillations can be numerically predicted. To this end, the silo structures are modeled using a finite element (FE) model and the w...

We present experimental results on the effect that inserting an obstacle just above the outlet of a silo has on the clogging process. We find that, if the obstacle position is properly selected, the probability that the granular flow is arrested can be reduced by a factor of 100. This dramatic effect occurs without any remarkable modification of the flow rate or the packing fraction above the o...

Germany has been officially free of bovine tuberculosis since 1996. However, in the last years there has been an increase of bovine tuberculosis cases, particularly in the southern part of Germany, in the Allgäu region. As a consequence a one-time tuberculosis surveillance program was revisited with different premortal and postmortal tests. The aim of this paper was to estimate diagnostic sensi...