Until recently, essentially all of our information concerning the biosynthesis of leucine stemmed from experiments with CY4labeled intermediates. Ehrensvard et al. (l), in experiments with yeast grown on C4-labeled acetate as the sole carbon source, showed that the carboxyl carbon of leucine is probably derived from the carboxyl of acetic acid. In isotopic competition experiments, Abelson and V...

OBJECTIVES To describe the clinical results (both early and at follow-up) of patients currently receiving extracorporeal membrane oxygenation (ECMO) therapy for cardiac and/or pulmonary failure. To assess the effect of indications, clinical presentations and ECMO modalities on early/late clinical outcomes. To identify baseline factors associated with worse survival at follow-up. METHODS We re...

Chen et al. [1] succeeded in improving the SAVE score in patients who received extracorporeal membrane oxygenation (ECMO) for cardiogenic shock (CS) by simple addition of blood lactate. Accordingly, many other scores have been determined for outcome prediction for patients already receiving ECMO for CS; some reported by the authors and others being published afterward [2]. Enthusiasm in these s...

Aim. To identify predictors of 3-month mortality after heart transplantation in a Croatian academic center. Methods. A retrospective review of institutional database identified 117 heart transplantations from January 2008 to July 2014. Two children <14 years were excluded from the study. The remaining 115 patients were dichotomized into survivors and non-survivors adjudicated at 3-months postop...

The physical exercise is considered beneficial contributing for physical, psychological and social wellbeing and balance of the individual, being able to delay the aging process. The physical exercise unchains a physiological stress situation, to which, the sympathetic nervous system activity answers activating adaptation mechanisms. The availability of oxygen and the nitric oxide release, prov...

Exercise conditioning involves adaptations in the heart, peripheral circulation, and trained skeletal muscle that result in improved exercise capacity. Since the specific influence of /3adrenergic stimulation on these various adaptations has not been clear, we studied the effect of 3,1selective and nonselective ,B-adrenergic blockade on the exercise conditioning response of 24 healthy, sedentar...

This is the case of a young male admitted to the hospital for acute cardiac failure in chronic dilated cardiomyopathy due to aortic regurgitation (AR): the patient had previously refused aortic valve replacement (AVR) for the fear of postoperative outcome. He suffered from ongoing dyspnea and peripheral edema with a serious asthenia. Clinical conditions were poor with seriously impaired biventr...

Abstract Background Temporary mechanical circulatory support (MCS) could provide stabilization and improve prognosis in selected patients with cardiogenic shock (CS). Intra-aortic balloon pump (IABP) is a common percutaneous MCS device, characterized by wide availability, easy deployment low complication rate. Despite its use CS caused acute myocardial infarction has been discouraged based on a...

Liver ischaemia-reperfusion (I/R) injury occurs in a number o f clinical settings, including liver surgery, transplantation and haemorrhagic shock with subsequent fluid resuscitation. It is well recognised as a significant cause o f morbidity and mortality and characterised by oxidative stress accompanied with depletion o f antioxidants. Its pathophysiology is complex. This thesis investigates ...

Previous studies of contracting muscle with low loading and partial vascular occlusion demonstrated hypertrophy and strength adaptations similar to and exceeding those observed with traditional moderate to high resistance (Shinohara M, Kouzaki M, Yoshihisa T, and Fukunaga T. Eur J Physiol 77: 189-191, 1998; Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, and Ishii N. J Appl Physiol 88:...