The challenges associated with demonstrating a durable response using molecular-targeted therapies in cancer has sparked a renewed interest in viewing cancer from an evolutionary perspective. Evolutionary processes have three common traits: heterogeneity, dynamics, and a selective fitness landscape. Mutagens randomly alter the genome of host cells creating a population of cells that contain dif...

Capillarity approximation is used to study the free-energy landscape of nucleation when an intermediate metastable phase exists. The critical nucleus that corresponds to the saddle point of the free-energy landscape as well as the whole free-energy landscape can be studied using this capillarity approximation, and various scenarios of nucleation and growth can be elucidated. In this study, we c...

1. Lamont Doherty Earth Observatory, Palisades, New York 10964, U.S.A., [email protected] 2. U.S. Geological Survey, Menlo Park, CA 94025, U.S.A., [email protected] 3. University of Alaska Fairbanks, Fairbanks, AK 99775, U.S.A., [email protected] 4. Present address: Institute for Botany and Landscape Ecology, University Greifswald, Grimmer Strasse 88, Greifswald 17487, Germany, wilmking@uni-greifsw...

Cognitive ecology is a term that has been used in environments that are more tightly coupled and purposespecific than environments of everyday life. In this paper I consider cases from a cognitive ethnography of older adults. These cases show the analytical use of understanding the diachronic and synchronic cognitive ecology in which cognitive processes of everyday life occur. Specifically I di...

The study presents a landscape design project with a set of preliminary morphological analyses. Karaalioglu Park, in South Anatolia, is squeezed between a dense urban fabric and the irrevocably transformed edge of Mediterranean Sea. Globalisation, rapid urbanisation as much as other sociocultural imperatives and natural processes paved the foundations for dilapidation of the park. The project c...

POLLEN EVIDENCE has, to date, made little contribution to our understanding of the origins and development of the medieval landscape. Compared to the prehistoric period, relatively few long palaeoenvironmental sequences provide a continuous record for the past two millennia, and those that have been analysed are mostly located in upland locations that lay beyond areas settled during this period...

We quantified the wholesale transformation of the boreal landscape by open-pit oil sands mining in Alberta, Canada to evaluate its effect on carbon storage and sequestration. Contrary to claims made in the media, peatland destroyed by open-pit mining will not be restored. Current plans dictate its replacement with upland forest and tailings storage lakes, amounting to the destruction of over 29...

Although the Neotropics are recognized as a region rich in biological diversity, the origin, evolution, and maintenance of this phenomenon continues to be debated. Historical ecologists and landscape archaeologists point out that the Neotropics have a long, complex human history that may have been a key factor in the creation, shaping, and management of present day biodiversity. The constructio...

Wetlands provide many ecosystem services, including sediment and carbon retention, nutrient transformation, and water quality improvement. Although all wetlands are biogeochemical hotspots, geographically isolated wetlands (GIWs) receive fewer legal protections compared with other types of wetlands because of their apparent isolation from jurisdictional waters. Here, we consider controls on bio...

Automotive industry observers note that a transformation is occurring where automotive OEMs are delegating more responsibilities to their suppliers. Instead of purchasing individual components, the OEMs are purchasing sub-assemblies. The suppliers are expected to do their own engineering. Many in the CAE community realize that there are many challenges to be faced in coordinating CAE activities...