This paper explores a dual inhibition of main protease (Mpro) and nonstructural protein 10/nonstructural 16 (NSP16) methyltransferase complex as the key targets for COVID-19 therapy. These are based on new Schiff-base ligand that was obtained from condensation (4-chloro-3-methyl phenyl) hydrazine with 2-pyridine-carboxaldehyde its novel metal complexes. include Ni(II), Pd(II), Pt(II), Zn(II), H...

Novel mixed ligand bivalent copper complexes [Cu. L. A. ClO 4 ] and [Cu. L. A] where "L" is Schiff bases, namely 2-((3,4-dimethylisoxazol-5-ylimino)methyl)-4-bromophenol (DMIIMBP)/2-((3,4-dimethylisoxazol-5-ylimino)methyl)-4-chlorophenol (DMIIMCP), and "A" is heterocyclic compound, such as 1,10-phenanthroline (phen)/2,2(1)-bipyridyl (bipy)/8-hydroxyquinoline (oxine)/5-chloro-8-hydroxyquinoline ...

              The present work is focused on the degradation of 4-chloro-2-nitrophenol in aqueous solution containing nano titanium dioxide, hydrogen peroxide and the combination of nano-TiO2/H2O2. The effect of experimental parameters, such as the amount of nano- TiO2 concentration of H2O2, initial concentration of 4-chloro-...

Crystals of bis-(tetra-butyl-ammonium) di-μ3-chlorido--tris-(μ2-4-iodo-pyrazolato-κ2N:N')tris-[chlorido-cuprate(II)] 1,4-dioxane hemisolvate, (C16H36N)2[Cu3(C3H2IN2)3Cl5]·0.5C4H8O or (Bu4N)2[CuII3(μ3-Cl)2(μ-4-I-pz)3Cl3]·0.5C4H8O, were obtained by evaporating a solution of (Bu4N)2[{CuII(μ-OH)(μ-4-I-pz)} n CO3] (n = 27-31) nanojars in chloro-form/1,4-dioxane. The decomposition of chloro-form in t...

Protonation of the reactive intermediate produced in the  reaction between trimethyl phosphite and dimethyl acetylenedicarboxylate or diethyl acetylenedicarboxylate by resorcinol, 5-methylresorcinol, 2,5-dihydroxyacetophenone, 4-chloro-2-methylphenol, 4-chloro-3,5-dimethy-lphenol, 4-hydroxypyridine, 2-hydroxypyridine, 3-hydroxypyridine, or 8-hydroxyquinoline leads to vinylphosphonium salts,...

Objective(s): Melatonin, an important hormone secreted by the epiphysis, is a powerful anti-oxidant with a high potential to neutralize medical toxins. The goal of this study was to demonstrate the beneficial effect of melatonin on epididymal sperm and reproductive parameters in mice treated with acetylsalicylic acid (ASA).Materials and Methods:</stro...

Diphenyl(2-hydroxy-phenyl)phosphine was introduced as a ligand for gold(I) halides and pentafluorophenyl gold(I) in order to probe the interplay of intraand intermolecular interactions based on aurophilic (Au Au) and hydrogen bonding. 1:1 complexes of the type Ph2(2-HOC6H4)P-Au-X with X = Cl, Br, C6F5 have been prepared and characterized by analytical and spectroscopic data. The crystal structu...

treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine withdimethylthiocarbamoylchloride gave 7-chloro-n,n, 1,5-tetramethyl-1h-pyrimido[4,5-e][1,3,4]thiadiazin-3-amine in basic acetonitrile. the latter compounds were reacted withsecondary amines in boiling ethanol to afford the related 7-amino derivatives.