Hepcidin is a key regulator of iron metabolism. The expression of hepcidin is significantly induced by iron overload, inflammation, and infection of pathogens. Recent studies have indicated that the expression of hepcidin in the liver is also regulated during liver regeneration. However, the mechanism of the regulation of hepcidin expression and its role in liver regeneration remain unclear. In...

Nerve growth factor (NGF) and laminin are important factors for neural development and regeneration. We examined the effects of increasing the local concentration and duration of action of NGF and laminin on peripheral nerve regeneration in the adult mouse sciatic nerve. A Silastic (silicone rubber) channel with intraluminal NGF solution was secured between transected nerve ends. The second cha...

introduction recently topical 3% diclofenac is commonly used to treat actinic keratosis (ak). it is proposed that it may also have a potential effect on hair growth. case presentation three male patients were visited in the dermatology department and received treatment with topical 3% diclofenac gel because of scalp ak. all patients also had concomitant androgenetic alopecia (aga). during the f...

the purpose of this study was to evaluate the efficacy of two types of bone substitutes, bio-oss and nuoss, for repair of bone defects.this study was performed on the calvaria of 14 new zealand rabbits. the 6mm critical size defect (csd) models of bone regeneration were used. three csds were created in each surgical site. the first defect was filled with nuoss, the second one with bio-oss and t...

A healthy diet rich in fruits and vegetables is an important part of a healthy lifestyle. Whereas epidemiological data sometimes fail to provide proof of this concept, molecular evidence is accumulating that clearly shows both preventive as well as therapeutic effects of compounds from natural origins. in the paper of Guido Kroemer's group about pro-autophagic polyphenols and their inhibitory e...

A healthy diet rich in fruits and vegetables is an important part of a healthy lifestyle. Whereas epidemiological data sometimes fail to provide proof of this concept, molecular evidence is accumulating that clearly shows both preventive as well as therapeutic effects of compounds from natural origins. in the paper of Guido Kroemer's group about pro-autophagic polyphenols and their inhibitory e...

Recent studies have suggested that selective targeting of overexpressed enzymes in cancer cells by small molecules that induce the formation of reactive oxygen species (ROS) could be a viable approach in cancer therapy. One such example is the inactivation of ubiquitin specific protease-2 (USP2)—an emerging drug target to combat prostate cancer—by b-lapachone, which has been identified to invol...