In this observation a total of 140 schistosomula of schisto­soma mansoni and 36 schistosomula of schistosoma haematobium which were obtained from 36 Laboratory albino mice,each infec­ted with 1000 cercaria were studied.The animals were sacrificed in a certain intervals and the schistosomula from the skin, lung and liver were collected by special technique. The result of this study showed that t...

We report a case of human nasal myiasis caused by flower fly larva in a 14-year-old rural girl in Central Province of Iran. Entomological studies on larva showed the larva as Eristalis tenax which is a rarely cause of nasal myiasis. This is the first reported case of E. tenax larva causing human nasal myiasis in Iran.

A 54-year-old man with diabetes mellitus had a blood test and was found to have a blood eosinophilia (1,028/mm 3 ). Liverfunction tests were normal. A hepatic nodule was detected on screening of upper abdominal and renal sonography. Contrastenhanced computed tomography (CT) scan ( Figure 1 ) showed a small, oval, low-attenuating nodule in the right hepatic lobe. CT scans obtained 3, 6, and 10 m...

CCR-3 is a major receptor involved in regulating eosinophil trafficking. Initial analysis of chemokine receptors has demonstrated unique receptor events in different cell types, indicating the importance of investigating CCR-3 events in eosinophilic cell lines. We now report that the eosinophilic cell line, acute myelogenous leukemia (AML) 14.3D10, expresses eosinophil granule proteins and eota...

Current therapies for asthma are aimed at controlling disease symptoms and for the majority of patients inhaled glucocorticoid anti-inflammatory therapy is both effective and well-tolerated. However, concerns remain about the adverse effects of glucocorticoids while a subset of asthmatic patients remains symptomatic despite optimal treatment thereby creating a clear unmet medical need. There is...

The anti-inflammatory effects of long-term ethanol intoxication were determined during ethanol treatment and withdrawal on the basis of neutrophil and eosinophil migration, hind paw edema and mast cell degranulation. Male Wistar rats (180-200 g, around 2 months of age) were exposed to increasing concentrations of ethanol vapor over a 10-day period. One group was evaluated immediately after expo...

To examine whether cysteinyl leukotrienes (cysLTs: LTC4, LTD4 and LTE4) induce symptoms of allergic rhinitis via their receptors, we studied the following: i) the specific binding of radiolabeled cysLTs to guinea pig nasal mucosa membrane and ii) effects of nasal LTD4 challenge in normal guinea pigs. The binding study indicated that there was a single population of binding sites for LTC4, LTD4 ...

1. The second-stage larva of the plant parasitic nematode Heterodera rostocfaensis shows very little movement while confined to the egg; on the other hand, the larva of the closely related Meloidogyne incognita is very active 2. Using interference microscopy, it is shown that the water content of the Heterodera larva increases immediately it is liberated from the egg while that of the Meloidogy...

We have evaluated a method for quantitation of eosinophil migration to stimuli in vivo. Upon transfusion into normal syngeneic mice, 111In-labeled eosinophils had an intravascular half-life of 9.5 hr and distributed predominantly into spleen, bone marrow, and liver. In either Schistosoma mansoni-infected mice or recipients of lymphoid cells from infected mice, intradermal (ear pinna) injection ...

Eosinophilic esophagitis (EoE) is a Th2 cytokine-associated disease characterized by eosinophil infiltration, epithelial cell hyperplasia, and tissue remodeling. Recent studies highlighted a major contribution for IL-13 in EoE pathogenesis. Paired Ig-like receptor B is a cell surface immune-inhibitory receptor that is expressed by eosinophils and postulated to regulate eosinophil development an...