BACKGROUND First-line therapy for primary open-angle glaucoma and ocular hypertension generally involves prostaglandin analogue therapy. The relative efficacy of differing prostaglandin therapy is disputed. METHODS A meta-analysis was conducted of head-to-head randomized trials of prostaglandin therapies. We included randomized trials assessing head-to-head evaluations of prostaglandin analog...

OBJECTIVE To compare the efficacy of latanoprost, bimatoprost and travoprost for lowering IOP in patients with glaucoma. RESEARCH DESIGN AND METHODS In order to carry out this meta-analysis, randomized trials (2001-2004) were identified on Medline and EMBASE using the following key words: glaucoma, ocular hypertension (OHT), randomization, trial, latanoprost, bimatoprost and travoprost. The s...

BACKGROUND Benzalkonium chloride (BAC) is a common preservative used in ophthalmic solutions. The aim of this study was to compare the cytotoxic effects of BAC-containing ophthalmic solutions with a BAC-free ophthalmic solution using an organotypic 3-dimensional (3-D) corneal epithelial model and to determine the effects of latanoprost ophthalmic solution and its BAC-containing vehicle on corne...

AIM To compare the efficacy and tolerability of latanoprost versus brimonidine in the treatment of open-angle glaucoma, ocular hypertension or normal-tension glaucoma. METHOD Systematic review of randomised controlled trials comparing latanoprost and brimondine, identified by searches including Medline, Embase and Cochrane Controlled Trials Register. Two reviewers independently assessed trial...

PURPOSE Matrix metalloproteinase (MMP)-mediated turnover of extracellular matrix (ECM) affects outflow resistance in the uveoscleral pathway. The balance of MMPs and tissue inhibitors of metalloproteinases (TIMPs) governs the rate of ECM turnover in many tissues. The hypothesis was that a differential effect on MMPs and TIMPs in ciliary body smooth muscle (CBSM) cells would relate to the relati...

Program Number: 2099 Poster Board Number: A0160 Presentation Time: 3:45 PM–5:30 PM Effect of Latanoprost on Aqueous Humor Dynamics with an Objective Method of Episcleral Venous Pressure Measurement in Normal Eyes Arash Kazemi1, Jay W. McLaren1, Shuai-Chun Lin1, Carol B. Toris2, 3, Vikas Gulati3, David M. Reed4, Sayoko E. Moroi5, Arthur J. Sit1. 1Ophthalmology, Mayo Clinic, Rochester, MN; 2Ophth...

Aspects on prostanoid and cholinergic effects on aqueous humour dynamics in human eyes Christina Lindén Department of Ophthalmology, Umeå University, S-901 85 Umeå, Sweden The discovery of the ocular hypotensive effect of topically applied prostaglandins (PGs) has raised a number of questions about the mechanisms of action involved. The aim of the present thesis was to answer some of these ques...

Objective of this study was to evaluate the intraocular pressure-reducing effect of latanoprost as monotherapy after replacing current dual therapy in glaucoma patients. The 6-months study comprised 189 patients with primary open angle glaucoma who were treated at least 6 months with two different kind of topical medications (beta-blockers, pilocarpine, dorzolamide and brimonidine). Due to loca...

Objective(s): Evaluate the effect of topical antiglaucoma drugs on tear film and determine the time taken to develop symptoms and or signs of dry eye in diagnosed open angle glaucoma patients by Schirmer's test I, Schirmer's test II, Tear film break up time. Method(s): This prospective study was carried out in 60 patients attending Ophthalmology outdoor with newly diagnosed patients of primary ...

PURPOSE To quantify changes in tear break-up time (TBUT), corneal staining and ocular surface disease index (OSDI) in glaucoma patients after switching therapy from latanoprost with 0.02% benzalkonium chloride (BAK) to travoprost with sofZia(). METHODS Prospective consecutive case series evaluating patients before and 8 weeks after switching from latanoprost with BAK to travoprost with sofZia...