We examined the clonal evolution of skin malignant lesions by repeated topical applications of 20-methylcholanthrene (20-MC) to the skin, which induces hyperplastic epidermis, papillomatous lesion and invasive carcinoma in mice. The lesions were examined histologically and immunohistochemically with anti-single-stranded DNA after acid hydrolysis (DNA-instability test), p53, VEGF, DFF45, PCNA an...

background pompe disease is an inherited metabolic disorder characterized by α-glycosidase deficiency, which leads to lysosomal glycogen accumulation in many different tissues. the infantile form is the most severe with a rapidly fatal outcome, while the late onset form has a greater phenotypic variability, characterized by skeletal muscle dysfunction and early respiratory involvement. bone min...

Birt-Hogg-Dubé syndrome (BHDS) is a rare autosomal dominant genodermatosis that presents as a clinical triad including follicular hamartomas, renal neoplasms and lung cysts associated with an increased risk of pneumothorax. FLCN gene defects have been identified as being responsible for BHDS. We herein report the case of a 67-year-old woman with the full-blown BHDS phenotype, characterized by s...

Sulfur mustard is a vesicant agent with severe irritating effects on living tissues, including skin, mucous membranes, eyes, and the respiratory tract. The eyes are the most susceptible tissue to mustard gas effects, and varying degrees of ocular involvement are seen in 75% to 90% of exposed individuals. Most cases resolve uneventfully; however, a minority of exposed patients will have a contin...

Objectives Inborn errors of immunity (IEIs) are monogenic diseases the immune system. Despite increasing genetic advancements, diagnosis IEIs still lean on clinical diagnosis. Dermatological manifestations observed in a large number IEI patients and can lead to proper approach prompt intervention. Methods This cross-sectional study was carried out between 2018 2020 at Children's tertiary care c...

In the Amadeus study, 1 patients in atrial fi brillation who had an increased risk of thromboembolic stroke were randomly assigned either a vitamin K antagonist or a weekly subcutaneous injection of idraparinux—a synthetic pentasaccharide that inhibits activated factor X. The study was stopped early because of excessive bleeding in patients assigned idraparinux. We report unusual skin lesions t...

Background: Beta-thalassemia major (BTM) is a genetic disorder, which is common in Kerman province of Iran. New methods of care has increased their survival. Objective: The objective of this descriptive study was to assess the frequency of skin and mucosal complications of BTM patients. Patients and Methods: All BTM patients referred to Kerman-Darman Hospital in 1377 (150 cases) were evaluated....

background: granulomatous dermatoses are common skin pathology, often need histopathological confirmation for diagnosis. histologically six sub-types of granulomas found in granulomatous skin diseases- tuberculoid, sarcoidal, necrobiotic, suppurative, foreign body & histoid type. the aims of the present study were clinico-pathological evaluation of granulomatous skin lesions and their etiol...