INTRODUCTION With an ageing population, end-of-life care is increasing in importance. The present work investigated characteristics and time trends of older peoples' attitudes towards euthanasia and an end-of-life pill. METHODS Three samples aged 64 years or older from the Longitudinal Ageing Study Amsterdam (N=1284 (2001), N=1303 (2005) and N=1245 (2008)) were studied. Respondents were asked...

In this method for identifying autoantibodies to lactate dehydrogenase (anti-LDs) in serum, we used immobilized Protein G to bind IgG-complexed LD and immobilized jacalin to bind IgA-complexed LD, leaving non-complexed LD in solution. The non-complexed LD and total LD were kinetically measured. We report results as LD bound to immobilized Protein G and LD bound to immobilized jacalin. Using ser...

OBJECTIVE The increasing prevalence of obesity and related metabolic disorders coincides with increasing exposure to light at night. Previous studies report that mice exposed to dim light at night (dLAN) develop symptoms of metabolic syndrome. This study investigated whether mice returned to dark nights after dLAN exposure recover metabolic function. DESIGN AND METHODS Male Swiss-Webster mice...

Background Long-term antiretroviral therapy (ART) adherence is critical for achieving optimal HIV treatment outcomes. Fixed-dose combination (FDC) single-pill regimens, introduced in South Africa in April 2013, has simplified pill taking. We evaluated treatment outcomes among patients initiated on a FDC compared to a similar multi-pill ART regimen in Johannesburg, South Africa. Methods We con...

BACKGROUND Prescribing inappropriate pill splitting is not rare in clinical practice. To reduce inappropriate pill splitting, we developed an automatic warning system linked to a computerized physician order entry (CPOE) system for special oral formulation drugs in outpatient settings. We examined the impact of the warning system on inappropriate prescribing of pill splitting and assess prescri...

The aim of the present study was to observe the effect of zhenbao pill on the motor function of acute spinal cord injury (ASCI) rats and the molecular mechanisms involving miR-146a-5p and G-protein-coupled receptor 17 (GPR17). ASCI rat model was established by modified Allen method, and then the rats were divided into three groups. SH-SY5Y cells were cultured overnight in hypoxia condition and ...

OBJECTIVE To determine if simple adherence measures, such as twenty-four hour recall and refill history, are accurate for routine use, compared to more time-consuming measures such as pill counts. DESIGN Randomized, double-blind, placebo-controlled trial. SETTING Walter Reed Army Medical Center, a tertiary medical center in Washington. PATIENTS Men and women >30 years old with known coron...

Dramatic improvements in fertility control mark some of the most significant technological changes of the twentieth century, and so it seems paradoxical that the same period saw widespread and large increases in non-marital births. We link these two trends and examine the effect of increased access to the birth control Pill on non-marital childbearing and shot-gun marriage rates, along with oth...

the purpose of this study was to determine the adherence to oral hypoglycemic medications and associated factors in type 2 diabetes mellitus patients who were referred to the isfahan endocrinology and metabolism research centre (iemrc). convenience sampling was used to enroll 248 patients with type 2 diabetes in a prospective study at iemrc from january 2007 to january 2008. patients had to be ...

OBJECTIVE To evaluate the motivators and barriers to the use of the combined oral contraceptive pill among Hong Kong women. METHODS The Family Planning Association of Hong Kong commissioned the ESDlife to launch an online survey and invited its female members aged 18 to 45 years who had used contraceptives in the past 12 months to participate in this survey. The online survey was posted on th...