Replication, transcription, and translation stress all lead to stalling of their respective polymerases (DNA polymerase, RNA polymerase, and the ribosome), and the cell must respond to these events in order to preserve macromolecular integrity. In response to replication stress such as DNA damage, the cell activates a checkpoint and promotes repair or bypass at the lesion. Transcriptional stres...

substantial progress in documenting the role of psychosocial stress in the etiology and development of physical and mental disease has been made in the past 10 years. although the exact mechanisms with which stress impacts health are not fully understood, it is thought that the negative emotional and cognitive effects of stress alter the immune response and increase susceptibility to disease. s...

background: cardiovascular disease (cvd) is one of the leading causes of death in the world. one of its most insidious forms is coronary heart disease (chd) which decreases patient's quality of life. research indicates that psychological factors are interrelated with coronary heart disease patients' quality of life. in the present study, the role of type d personality and emotional intelligence...