Yuval Elhanati1†, Zachary Sethna1†, Curtis G. Callan Jr., Thierry Mora2∗, Aleksandra M. Walczak3∗ Joseph Henry Laboratories, Princeton University, Princeton, New Jersey 08544 USA 2 Laboratoire de physique statistique, CNRS, Sorbonne Université, Université Paris-Diderot, and École Normale Supérieure (PSL University), 24, rue Lhomond, 75005 Paris, France Laboratoire de physique théorique, CNRS, S...

The mechanism by which the ligand occupancy state of the T cell receptor complex is converted into intracellular signaling information has been a controversial topic. Although the majority of structural studies argue against a conformational change, recent studies support the possibility for such a change within the CD3 components of the TCR complex. In this commentary, the evidence for TCR con...