A growing body of evidence suggests that mitochondrial proton-leak functions as a regulator of reactive oxygen species production and its modulation may limit oxidative injury to tissues. The main purpose of this work was to characterize the proton-leak of brain cortical mitochondria from long-term hyperglycemic and insulin-induced recurrent hypoglycemic rats through the modulation of the uncou...

Pneumothorax is a relatively common condition that is usually managed either conservatively, by chest tube drainage or, if a refractory air leak persists, then with cardiothoracic intervention. However, there is a small group of patients with a persistent air leak in whom surgical intervention is felt to be inappropriate. This study looks at a novel management strategy in a patient presenting w...

Maintenance of vascular integrity is critical for homeostasis, and temporally and spatially regulated vascular leak is a central feature of inflammation. Sphingosine-1-phosphate (S1P) can regulate endothelial barrier function, but the sources of the S1P that provide this activity in vivo and its importance in modulating different inflammatory responses are unknown. We report here that mutant mi...

Leak localization is essential for the safety and maintenance of storage vessels. This study proposes a novel circular acoustic emission sensor array to realize the continuous CO₂ leak localization from a circular hole on the surface of a large storage vessel in a carbon capture and storage system. Advantages of the proposed array are analyzed and compared with the common sparse arrays. Experim...

OBJECTIVE To determine the etiology and site of leak of cerebrospinal fluid (CSF) rhinorrhea and the surgical efficacy of Functional Endoscopic Sinus Surgery (FESS), in closing the defect of CSF leak by different graft materials. STUDY DESIGN Case series. PLACE AND DURATION OF STUDY Department of ENT-Head and Neck Surgery, Dow University of Health Sciences, Karachi, from September 2005 to D...

Possibility of a system leakage in an air-conditioning system always exists. Once a leakage occurs refrigerant and oil escape from the system and compressor. This paper determines the characteristics of the losses. Two important factors affecting the loss characteristics are location of leakage in the system and speed ofleakage or leakage rate. This paper then reasons the tested actual loss cha...

ered self-expandable metal stents (FCSEMSs) has been described for the treatment of complex bile leaks after laparoscopic or open cholecystectomy [1,2]. A 72-year-old woman developed a bile leak after an open cholecystectomy (●" Fig. 1). An initial attempt at closure with plastic stents was unsuccessful (●" Fig. 2). Therefore, it was decided to use a 10-mm diameter, 8-cm long FCSEMS (WallFlex; ...

Management of upper gastrointestinal anastomotic leaks is an inter-disciplinary challenge. We present a case of late pyloroplasty leak following 3-stage oesophagectomy. We describe a novel, combined endoscopic and fluroscopic procedure to introduce a T-tube into the anastomotic leak proving an ideal plug at the site of leak which enabled the patient to consume a normal diet and return home safely.

BACKGROUND Nasal noninvasive ventilation (NIV) is a common form of noninvasive respiratory mode used in newborn infants. A next-generation nasal cannula (Neotech RAM cannula) has recently been used to provide nasal NIV. The impact of the Neotech RAM cannula on the delivery of pressure needs to be studied. METHODS In this ex vivo experimental design, a lung simulator (IngMar ASL 5000, version ...