Background and aim: In spite of the existance of different types of treatment for cutaneous leishmaniasis, an efficient, safe and cheap treatment has not been found yet. There are some studies showing antiparasiticidal effect of direct current electricity both in vivo and in vitro. The objective of this study was to evaluate the effect of electrotherapy in treatment of cutaneous leishmani...

Background: Humans, rodents and sandflies have role in transmitted cycle of cutaneous leishmaniasis. To control the disease, promoting the environment, killing the rodent and poisoning the vectors are recommended, individually all over the world. Since, there is no effective vaccine against this disease, the integration of methods is considerable. Objective: To evaluate the efficacy of integrat...

Introduction: In terms of the global burden diseases, leishmaniasis is third most serious and often fatally untreated tropical disease. The number people suffering from estimated to be 12–15 million. Because comparatively underestimated reported cases, not seen as an immediate health issue in various regions by local international policymakers. Therefore, strong evidence required for policymake...

BACKGROUND A recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi (rLdccys1) was previously shown to induce protective immune responses against murine and canine visceral leishmaniasis. These findings encouraged us to use rLdccys1 in the immunotherapy of naturally infected dogs from Teresina, Piauí, a region of high incidence of visceral leishmaniasis in Brazil. METHO...

Leishmaniasis is a zoonotic and vector-borne infectious disease that caused by the genus Leishmania belonging to trypanosomatid family. The protozoan parasite has digenetic life cycle involving mammalian host an insect vector. Leishmaniasisis worldwide public health problem falling under neglected tropical category, with over 90 endemic countries, approximately 1 million new cases 20,000 deaths...

Leishmania (L.) tropica is a causative agent of cutaneous leishmaniasis, and occasionally of visceral or viscerotropic leishmaniasis in humans. Murine models of Leishmania infection have been proven to be useful for elucidation of mechanisms for pathogenesis and immunity in leishmaniasis. The aim of this study was to establish a murine model for human viscerotropic leishmaniasis, and the growth...