BACKGROUND To assess the efficacy of luteal phase support (LPS) using intravaginal progesterone (P) on pregnancy rate in Iranian women with polycystic ovarian syndrome (PCOS) who used a combination for ovulation induction consisting of letrozole or clomi- phene citrate (CC) and human menopausal gonadotropin (HMG). MATERIALS AND METHODS This was a randomized clinical trial undertaken in a fert...

OBJECTIVE To determine the cost-effectiveness of initiation of second-line hormone therapy with letrozole in the treatment of advanced breast cancer in postmenopausal women in Canada, compared to megestrol acetate. METHODS A modified Markov model, incorporating seven health states, was designed to simulate the treatment of patients with advanced breast cancer from second-line hormone therapy ...

PURPOSE Controversy exists regarding estrogen (ER) and progesterone (PgR) receptor expression on efficacy of adjuvant endocrine therapy. In the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial, the benefit of anastrozole over tamoxifen was substantially greater in ER+/PgR-than ER+/PgR+ tumors. In BIG 1-98 (Breast International Group), the benefits of letrozole over tamoxifen were the s...

In this study, we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of estrogen receptor (ER) and human epidermal receptor-2 (Her-2) signaling. We used human ER-positive breast cancer cells stably transfected with the aromatase gene (MCF-7Ca). These cells grow as tu...

OBJECTIVE  To compare the effectiveness of alternative first line treatment options for women with WHO group II anovulation wishing to conceive. DESIGN  Systematic review and network meta-analysis. DATA SOURCES  Cochrane Central Register of Controlled Trials, Medline, and Embase, up to 11 April 2016. STUDY SELECTION  Randomised controlled trials comparing eight ovulation induction treatme...

Background: Letrozole, an aromatase inhibitor has been regarded as the first line drug for ovulation induction in anovulatory PCOS patients because of its monofollicular growth and there is no chance hyperstimulation by letrozole. Traditional protocol letrozole includes administration 5 days half follicular phase which induces 61.7% cases. Few recent studies have shown that extended causes more...

background : to determine the role of letrozole, an aromatase inhibitor,in the treatment of endometriotic pain.   methods: in this prospective, randomized, controlled clinical trial in minimallyinvasive surgery research center,51 women with pelvic endometriosis and endometriotic pain (dyspareunia, dysmenorrhea, pelvic pain) score of 5 or more (for at least one of these endometriotic pain), afte...

Introduction: Histone deacetylase (HDAC) inhibitors have been found to reverse the epigenetic profile of some genes, including estrogen receptor (ER), epidermal growth factor receptor (EGFR), and retinoic acid receptor (RAR) -β2 (1). Here we have studied the metabolic effects of the HDAC inhibitor MS-275, the aromatase inhibitor letrozole, and their combination in vivo in the ER/PR/Her-2 negati...

This systematic review aims to assess the efficacy of aromatase inhibitors (AIs) in treating pain symptoms caused by endometriosis. A comprehensive literature search was conducted to identify all the published studies evaluating the efficacy of type II nonsteroidal aromatase inhibitors (anastrozole and letrozole) in treating endometriosis-related pain symptoms. The MEDLINE, EMBASE, PubMed, and ...

OBJECTIVE To evaluate the clinical response and endometrial morphology during the implantation window on ovarian hyperstimulation with the aromatase inhibitor letrozole in infertile ovulatory women. DESIGN Prospective trial in infertile patients. SETTING Tertiary care hospital. PATIENT(S) Eight ovulatory infertile patient candidates for ovarian superovulation. INTERVENTION(S) Subjects w...