The prevalence of diabetes is increasing worldwide with the trend of patients being young and creating a significant burden on health systems, including reproductiveproblems,but theeffectsofdiabeteson embryo implantation are still poorly understood. Our study was to examine effects of diabetes on mouse embryo implantation, providing experimental basis for treating diabetes and its complications...

Background Polycystic ovarian syndrome (PCOs) is one of the most common causes of infertility in women of reproductive age. Currently, one of the best therapeutic options for PCOs patients is ICSI. Moreover, IVM can be a useful technique for women with PCOs who are at the risk of ovarian hyperstimulation syndrome (OHSS). On the other hand, the oocyte quality can be a determining factor for outc...

BACKGROUND The purpose of this study was to investigate the in vitro survival and developmental potential of oocytes obtained from vitrified mouse ovaries transplanted to a heterotopic site. MATERIALS AND METHODS In this experimental study, two-week-old mice were unilaterally ovariectomized after anesthesia. The ovaries were vitrified by cryotop. After two weeks, the ovaries were thawed and a...

Initial attempts at obtaining a pregnancy by in vitro fertilization and embryo transfer (IVF-ET) were conducted in a natural cycle (Edwards et al., 1980). It soon became clear that ovarian stimulation using gonadotropins provided a useful tool to obtain more oocytes and increase the chance for success. This resulted in the need to monitor ovarian stimulation, based on serial sonographic assessm...

BACKGROUND The advances in the world of IVF during the last decades have been rapid and impressive and culture media play a major role in this success. Until the 1980s fertility centers made their media in house. Nowadays, there are numerous commercially available culture media that contain various components including nutrients, vitamins and growth factors. This review goes through the past, p...

Recent evidence shows that through best standard operating procedures, chances of successful pregnancy and live birth delivery rates are less than 50%. Repeated Implantation Failure (RIF) following transfer of one or more numbers of cleavage or blastocyst stage embryos is the main cause of low pregnancy rate in IVF cycles; therefore, finding the causes and modifying treatment protocols to incre...

OBJECTIVE To test the developmental competence of oocytes in a nonhCG-triggered in vitro maturation (IVM) system when oocyte-cumulus complexes (OCC) are retrieved from antral follicles with a diameter of <6 mm. DESIGN Prospective cohort study. SETTING Tertiary university-based referral center. PATIENT(S) From January 2010 to September 2011, 121 patients with polycystic ovaries/polycystic ...