نتایج جستجو برای: lifetime cancer risk
تعداد نتایج: 1784804 فیلتر نتایج به سال:
Genetic screening for BRCA1 and BRCA2 gives women the opportunity for early detection, surveillance, and intervention. One key feature of genetic testing and counseling is the provision of personal lifetime risk. However, little attention has been paid to how women interpret lifetime risk information, despite the fact that they base screening, treatment and family planning decisions on such inf...
The lifetime risk of having epileptic seizures is profoundly increased in patients with cancer: about 20% of all patients with systemic cancer may develop brain metastases. These patients and those with primary brain tumours have a lifetime risk of epilepsy of 20-80%. Moreover, exposure to chemotherapy or radiotherapy to the brain, cancer-related metabolic disturbances, stroke, and infection ca...
OBJECTIVES Breast pain is a common but worrisome symptom, which can cause a significant psychological burden of cancer stress. It is not known whether breast cancer risk estimation models can be used as an adjunct to the clinical and radiological assessment in counseling women with mastalgia. The aim of our study was to compare the estimated breast cancer risk and screening outcomes between pat...
introduction artificial and natural radionuclides are found in diverse environmental compartments, such as water, soil, rocks, vegetables, animals, and human body tissues. as such, humans and environments are at constant exposure of these radiation types. in this research investigated specific activities of radionuclide and dose assessment of some species of mushrooms. materials and methods in ...
OBJECTIVE To investigate the influence of increasing age on the incidence and remaining lifetime risk of cardiovascular disease and cancer in a cohort of older men. DESIGN Prospective cohort study. SETTING United States. PARTICIPANTS 22,048 male doctors aged 40-84 who were free of major disease in 1982. MAIN OUTCOME MEASURES Incidence and remaining lifetime risk of major cardiovascular ...
BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cance...
Familial susceptibility to breast cancer accounts for 25% of all breast cancer cases. In familial breast cancer, mutations in the BRCA1, BRCA2, CHEK2, TP53 and PTEN genes account for 5–10% of breast and ovarian cancer cases overall. The prevalence of BRCA1 or BRCA2 mutations varies considerably between ethnic groups and geographical areas. Populationspecific mutations have been described in Ice...
The present study aims at evaluating the risk of Mutagen X (MX) (3-chloro-4-(dichloromethyl)-5-hydroxy-2 (5H)-furanone) and adverse health effects, associated with direct ingestion of chlorinated drinking water in west of Tehran, supplied by chlorinated drinking water from surface and underground water sources. For one year, MX concentrations in tap water samples has been measured for consumers...
Little is known about the potential carcinogenicity associated with routine application of diazinon, a common organophosphate insecticide. The authors explored a possible association of diazinon exposure with cancer risk in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina enrolled in 1993-1997. A total of 23,106 male applicators pr...
Risk factors for ovarian cancer may differ between pre- and postmenopausal women. The authors used data from a multiethnic, population-based, case-control study, conducted between 1993 and 1999 in Hawaii and Los Angeles, California, to examine whether menopause modified the effect of ovulation on ovarian cancer risk. A structured questionnaire was administered to 558 histologically confirmed ep...
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