Culture fluids from mouse peritoneal exudate cells inhibited [(3)H]thymidine incorporation by, and proliferation of, EL-4 leukemia cells, 3T3 cells, and mitogen-stimulated spleen lymphocytes. Inhibited EL-4 leukemia cells recovered their normal proliferative capacity when washed and incubated in normal medium. The inhibitory activity resided in a low-molecular-weight substance that could be abs...

In normotensive rats, increased renal pelvic pressure stimulates the release of prostaglandin E and substance P, which in turn leads to an increase in afferent renal nerve activity (ARNA) and a contralateral natriuresis, a contralateral inhibitory renorenal reflex. In spontaneously hypertensive rats (SHR), increasing renal pelvic pressure failed to increase afferent renal nerve activity. The in...

o-Methoxycinnamaldehyde has been isolated and purified from powdered cinnamon. The compound inhibits the growth and toxin production of mycotoxin-producing fungi. The substance completely inhibited the growth of Aspergillus parasiticus and A. flavus at 100 microgram/ml and A. ochraceus and A. versicolor at 200 microgram/ml. It inhibited the production of aflatoxin B1 by over 90% at 6.25 microgr...

In the previous paper the technical aspects of the mucin-clot prevention test which was standardized by McClean (1) have been described. Friou and Wenner (2) using the mucin-clot prevention test have demonstrated the clinical significance of an inhibitory substance in human serum capable of neutralizing an enzyme elaborated by a strain of hemolytic streptococcus. The amount of inhibitory substa...

1. The serum of rabbits treated intravenously with neosalvarsan, and of syphilitic patients treated intravenously with salvarsan or neosalvarsan, has a definite spirochaeticidal action upon Spirochoeta duttoni. 2. Although this spirochaeticidal action is exerted in vitro, it can be demonstrated only after the treated spirochaetae are injected into susceptible animals. 3. A curative action of th...

Cole, A. P., and Hargreaves, T. (1972). Archives of Disease in Childhood, 47, 415. Conjugation inhibitors and early neonatal hyperbilirubinaemia. Milk and serum were obtained from 50 mothers on the 6th day post partum and examined for inhibitory activity against bilirubin conjugation in rat liver slices. Neonatal serum bilirubin levels were also analysed at this time. There was no relation betw...