BACKGROUND Cilostazol reduces restenosis and repeat revascularization after endovascular therapy (EVT) in claudicant patients with femoropopliteal lesions. However, the efficacy of cilostazol in patients with critical limb ischemia (CLI) is unclear. Therefore, we investigated the effect of cilostazol on outcomes in patients with CLI. METHODS From January 2004 to December 2009, 618 patients (3...

BACKGROUND In a prospective, nonrandomized, consecutive series of tibioperoneal vessel angioplasty (TPVA), critical limb ischemia (CLI) patients' data were analyzed with regard to immediate and follow-up success. METHODS AND RESULTS TPVA was successful in 270 of 284 critically ischemic limbs (95%), with 167 limbs (59%) requiring dilatation of 333 ipsilateral inflow obstructions to access and ...

Femoro-popliteal PTA for the treatment of critical limb ischemia is frequently associated with unsatisfactory procedural success rates while directional atherectomy (DCA) has improved success rate since claudicant patients undergoing percutaneous treatment of femoro-popliteal obstructive disease. The aim of this prospective study is to evaluate the safety, efficacy and procedural success of DCA...

In 2019, the Global Vascular Guidelines on chronic limb-threatening ischemia (CLTI) introduced concept of limb-based patency (LBP) defined as primary a target artery pathway (TAP). The purpose this study was to investigate relationship between LBP and major adverse limb events following infrainguinal revascularization for CLTI. Consecutive patients undergoing CLTI 2016 2019 at single tertiary i...

BACKGROUND Patients with limb ischemia were associated with endothelial dysfunction. The purpose of this study was to determine whether autologous bone-marrow mononuclear cell (BM-MNC) implantation improves endothelial dysfunction in patients with limb ischemia. METHODS AND RESULTS We evaluated the leg blood flow (LBF) response to acetylcholine (ACh), an endothelium-dependent vasodilator, and...

Chronic tissue ischemia due to defective vascular perfusion is a hallmark feature of peripheral artery disease for which minimal therapeutic options exist. We have reported that sodium nitrite therapy exerts cytoprotective effects against acute ischemia/reperfusion injury in both heart and liver, consistent with the model of bioactive NO formation from nitrite during ischemic stress. Here, we t...

Coats, Paul, and Roger Wadsworth. Marriage of resistance and conduit arteries breeds critical limb ischemia. Am J Physiol Heart Circ Physiol 288: H1044–H1050, 2005; doi:10.1152/ajpheart. 00773.2004.—Atherosclerosis in a major leg artery leads to impaired blood supply, which normally progresses to critical limb ischemia. Atherosclerosis produces substantial alterations of structure and endotheli...

Background: Acute limb ischemia (ALI) is a sudden decrease in leg perfusion that threatens the viability of with symptom onset within 2 weeks. In peripheral artery disease (PAD) conditions, occlusion blood vessels can occur due to thrombosis or atherosclerotic plaque embolism, which called "acute on chronic ischemia". The development endovascular therapy has made this an important role restorin...

BACKGROUND Critical limb ischemia due to peripheral arterial occlusive disease is associated with a severely increased morbidity and mortality. There is no effective pharmacological therapy available. Injection of autologous bone marrow-derived mononuclear cells (BM-MNC) is a promising therapeutic option in patients with critical limb ischemia, but double-blind, randomized trials are lacking. ...